alexa Tumor-associated M2 Macrophage Promotes Esophageal Aenocarcinoma Cell Invasion And Is Associated With Lymph Nodal Metastasis
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Pathology
April 14-15, 2014 Hilton San Antonio Airport, TX, USA

Wenqing Cao
ScientificTracks Abstracts: J Clin Exp Pathol
DOI: 10.4172/2161-0681.S1.012
Abstract
The incidence of esophageal adenocarcinoma (EAC) has increased considerably in United States over the past several decades. Patients with EAC continue to have the worst prognosis with an overall survival rate of 15-25%. Early detection and selection of appropriate treatment strategy based on accurate cancer staging are the hope to improve patient survival. Lymph node metastasis (LNM) is a decisive factor for selecting aggressive therapeutic approaches today. However, prior to surgical resection, accurate cancer staging information, in particular lymph node status cannot be achieved. Tumor-associated macrophages (TAMs) are the dominant population in the tumor microenvironment and are composed of multiple distinct pro (M1) and anti (M2) tumoral subpopulations. Several lines of studies have indicated TAMs appear to have important functions in cancer invasion and metastasis. Very few studies are related to the development and progression of EAC. In this study, we investigated the roles of macrophage subtypes in EAC lymph node metastasis and the potential mechanisms. The number of M1 macrophage and M2 macrophage displayed opposite parallel change with progression of EAC. The increase of M2 macrophage and M2/M1 ratio that represented the alteration of balance between M2 and M1 were strongly associated with nodal spread and poor patient survival. The results from the cell studies indicated that M2 macrophage stimulated EAC cancer cell migration and invasion, which could be an important mechanism for nodal spread promoted. The M2/M1 ratio may be a sensitive marker to predict nodal spread and prognosis in early stage EAC.
Biography
Wenqing Cao, MD is a gastrointestinal pathologist and Assistant Professor at University of Rochester Medical Center. She received her Medical Degree from Tongji Medical University, China. She completed Anatomic and Clinical Pathology residency at Northwester University and Gastrointestinal Pathology fellowship at the Mount Sinai Medical Center. Since 1998, Dr. Cao has done extensive basic and clinical translational research in GI malignancies. She has published more than 20 papers in reputed journals and has been serving as an editorial board member.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords