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Dr.Rong Fang research is focused on elucidating the mechanisms involved in pathogenesis of and host defense against rickettsial diseases for more than 13 years. She have extensive experience in rickettsiology, molecular biology, humoral and cellular immunology with specific training and expertise in key research areas relevant to this grant application. She have served as a PI and co-PI on a NIH R21 and R01 grant. Recently, she was also awarded a highly competitive pilot grant as a project PI of a multi-project program on rickettsial endothelial cell immunity and pathobiology. she has studied the roles of dendritic cells, T regulatory cells and NK cells in protective immunity against rickettsial diseases by using different animal models. she has mentored young scientists and students from different levels, and received awards for excellence in mentoring graduate and high school students. she believe that she has the expertise and track record for my role as a co-mentor for Claire’s grant application.
Dr. Fang’s research interests focus on understanding of the immune regulatory mechanisms involved in the inability of the host defense system to control systemic infection with intracellular bacteria, such as rickettsiae. She is specifically interested in studying how dendritic cells mediate a defective innate immune response and a suppressed effector T cell response which lead to overwhelming infection in fatal acute spotted fever rickettsiosis. Her current research had explored the role of T regulatory cells in rickettsial infection in vivo and in vitro by using mouse models.
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