Autoimmune Mechanism Of Pathogenesis In Autism | 9192
Journal of Clinical & Experimental Pathology
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Autoimmunity is a major cause underlying many chronic diseases particularly those impacting the nervous system. There
are 85 or so human conditions that are generally considered as autoimmune diseases that affect an estimated 55-60 million
Americans across the entire lifespan. This number however never includes millions more people who suffer from autoimmune
disease of the nervous system, for example autism, Alzheimer?s disease, etc. Our laboratory investigations have recently shown
that an autoimmune mechanism of pathogenesis is also involved in autism, a disorder of the developing nervous system. We
analyzed autoimmune markers, cytokines and virus serology in blood samples of autistic and normal children and also in
the CSF samples of some autistic children. Laboratory methods included enzyme-linked immunosobent assay (ELISA) and
protein immunoblotting assay. We found that many autistic children harbored elevated levels of pro-inflammatory cytokines
(e.g. interferon-gamma and interleukin-12), acute-phase protein (e.g. C-reactive protein), brain-specific autoantibodies [e.g.
antibodies to myelin basic protein (anti-MBP) and antibodies to caudate nucleus (anti-CN)], antibodies to measles virus, and
a positive response to immunotherapy. CSF samples were also positive for antibodies to brain antigens and measles virus. Of
considerable importance to autoimmune pathogenesis, we found a positive correlation between brain autoantibodies (anti-MBP)
and virus serology (anti-measles virus). Taken together, our laboratory findings demonstrated a pathological role of autoimmunity
in autism or a major subset thereof, we refer this subset as ?Autoimmune Autistic Disorder (AAD)?.
Vijendra K. Singh pursued his graduation from Lucknow University (India) and received his Ph.D. in Brain Biochemistry from the University of British
Columbia, Vancouver, BC, Canada. Subsequent to a post-doctoral fellowship in Neurochemistry and Immunology, he specialized in Neuroscience,
Neuroimmunology, Clinical Immunology, and Laboratory Medicine. Until retirement recently, he held faculty appointments at the University of British
Columbia, University of Michigan, Utah State University, and Medical University of South Carolina. He is a long-term active member of the Society
for Neuroscience (SfN) and a former member of the American Academy of Anti-Aging Medicine (A4M), American Academy of Neurology (AAN),
American Association for the Advancement of Science (AAAS), American Association of Immunologists (AAI) and American Society for Microbiology
(ASM). He is also a member of prestigious International Who?s Who of Intellectuals (UK) and American Men and Women in Science (USA). He was
also a member of the Scientific Advisory Board of several non-profit Organizations and/or Foundations. For his research contributions, Dr. Singh
has been honored with a Humanitarian Award from the Psychiatric Association of Philadelphia and National Foundation for Alternative Medicine
(NFAM) in Washington, DC. Currently, he works as an independent Professor of Neuroimmunology through a research program known as the
?Neuro Immune Biotechnology Solutions (NIBS)?. He is a professional neuroscientist and immunologist, speaker, author, biomedical researcher and
consultant for autoimmunity and inflammation in brain disorders. The focus of his research is to uncover novel therapies for autoimmune pathology
of nervous system disorders, including autism.
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