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Chitosan-polyvinyl alcohol co-polymerized films: Synthesis and exploring its pharmaceutical applications
3rd International Conference and Exhibition on Biopolymers & Bioplastics
Neha Mulchandani, Nimish Shah and Tejal Mehta
Nirma University, India
Posters & Accepted Abstracts: J Bioremed Biodeg
Abstract
Chitosan being a biopolymer can be co-polymerized with polyvinyl alcohol (PVA), which has excellent mechanical properties. The current work focuses on co-processing a natural polymer with a synthetic polymer to obtain a polymer with improved functional properties. The developed co-polymerized films were explored as an excipient and other drug delivery applications. Chitosan was blended to polyvinyl alcohol in different ratios, chemically modified by using initiators and crosslinking agents and the modified co-polymer was converted to films by solvent casting method. The films were evaluated for tensile strength, folding endurance, water uptake capacity, disintegration behavior and elongation. The developed copolymerized film was found to have excellent film forming ability and thus can have various applications in drug delivery. A model drug was loaded to the co-polymerized film having desired properties and the dissolution experiments were carried out to obtain the drug release profile. The films were characterized using Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) to identify the structural and morphological properties. The process and formulation parameters were optimized for the co-polymerized film. The results showed the potential of the developed films for applications in topical, buccal and oral controlled drug release.Biography
Email: neha170891@gmail.com
