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Dr. Holbrook has been working in the field of arbovirology since 1998 and with BSL-4 pathogens since 2003. Dr. Holbrook is considered a worldwide expert in tickborne flaviviruses and has developed significant expertise with all human pathogenic flaviviruses, particularly yellow fever virus.
Dr. Holbrook has also developed practical expertise with most BSL-4 pathogens, with experience working with Nipah and Hendra viruses, filoviruses, Rift Valley fever virus, and highly pathogenic arenaviruses.
Dr. Holbrook’s work has included the development of diagnostic agents as well as the testing of a number of different vaccines and chemotherapeutic agents against BSL-3 and BSL-4 viruses, in addition to extensive research experience in viral pathogenesis, viral immunology, viral protein expression and characterization, viral structure, and molecular virology.
Dr. Holbrook has served as principal investigator, co-investigator, and consultant on a number of National Institutes of Health-supported grants and contracts.
tickborne flaviviruses,human pathogenic flaviviruses, particularly yellow fever virus, development of diagnostic agent and testing of various vaccines.