alexa Lin Li | Clemson University

Journal of Chemical Biology & Therapeutics
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Lin Li

Lin Li Lin Li
Clemson University
United States

Education and work experience:
•Research Associate (Biophysics), Clemson University, 2013-now
•Post Doct (Biophysics), Clemson University, 2011-2013
•Ph.D. (Biophysics), Huazhong University of Science and Technology, 2005-2011
Research experience:
DelPhi Development: DelPhi is a widely used Poisson Boltzmann Equation solver. I have developed a Gaussian smooth method to DelPhi software, which is used to model the inhomogeneous dielectric properties of macromolecules. This method has been proved to be more accurate than the traditional 2-dielectric constant methods.

MEMPOT: A Membrane Potential (MEMPOT) tool is developed and implemented into DelPhi program. Using this MEMPOT tool, one can easily calculate the electrostatic potential distribution across the membrane.

ASPDock: He have developed a docking algorithm (ASPDock) to calculate binding free energy of protein complexes, which improves the accuracy of prediction effectively. Comparisons with other state-of-the-art docking algorithms showed that ASP score indeed gives higher success rate than the pure shape complementarity score of FTDock.

SRM: He also developed a Softly Restricting Method (SRM), which utilizes the unreliable binding site information to enhance success rate of docking. It only reduces hit count number and success rate slightly if the predicted information is completely wrong. However, when the predicted information is correct or partially correct, SRM increases the hit count number and success rate significantly.

CAPRI: Using ASPDock and Softly Restricting Method, his team has participated in two rounds of Critical Assessment of PRediction of Interactions (CAPRI). We got high-quality hits for T40 and T41 and the best LRMSD were 2.35 Å and 1.41 Å, respectively.
2001-2002: HUST Scholarship
2002-2003: National Scholarship by Chinese Government
Skills and Software
Programming language: Fortran/C/C++/Bash/Matlab
Molecular Simulatons: DelPhi/Tinker /NAMD
Protein-protein docking: ASPDock/SRM/FTDock/ZDOCK/GRAMM
Graphic: Chimera/PyMOL/Photoshop/Flash
Homology Modeling: SWISS-MODEL/I-TASSER

Research Interest

1.Protein electrostatic calculations ;
2.Molecular dynamic simulations;
3.Protein-protein interactions, Protein-RNA/DNA interactions, Protein-ligand docking;
4.Structure, function, chemistry, and in vivo modification and processing of proteins, nucleic acids, and other biologically important macromolecules;
5.Computational method for protein/DNA/RNA simulations.


Global Speakers in the subject

Global Experts in the subject


Emotional Distress in Newly Diagnosed Cancer Outpatients: Do Depression and Anxiety Predict Mortality and Psychosocial Outcomes After 1 Year?
Jianlin Liu, Chao-Xu Peh, Shi Min Chua and Rathi Mahendran
Research Article: J Depress Anxiety 2017, 6: S11-005
DOI: 10.4172/2167-1044.S11-005
Mucinous Adenocarcinoma of Prostate: A Case Report and Review of Literature
Guang-Zhen WU, Wang Qi-Fei, Quan-Lin LI, Zhang Zhi-W and Tang QZ
Case Report: J Clin Case Rep 2017, 6: 955
DOI: 10.4172/2165-7920.1000955
Evasion of Innate Immunity by Dengue Virus Non-Structural Proteins through Interfereing with Type I Interferon Production and Jak/STAT Signaling
Haiyan Ye, Shilin Li and Limin Chen
Editorial: J Antivir Antiretrovir 2017, 9:e139
DOI: 10.4172/1948-5964.1000e139
Change in Bank Equity Stakes before Merger Completion
Paitoon Chetthamrongchai, Lin Lin, Hsaio-Fen Hsiaoand Yu-LunHuang
Research Article: J Account Mark 2017, 6:222
DOI: 10.4172/2168-9601.1000222
Differences, Correlation of Compositions, Taste and Texture Characteristics of Rice from Heilongjiang China
Fenglian Chen, Chunhua Yang, Linlin Liu, Tianyi Liu, Yang Wang, Lichao Wang, Yanguo Shi and Osvaldo H Campanella
Research Article: J Rice Res 2016, 5: 178
DOI: 10.4172/2375-4338.1000178
Lactobacillus Tritherapy for Cholesterol and Heart Diseases
Shousong Yue, Xinlin Liu and Jie Fu
Short Commentary: Journal of Microbiology and Biotechnology
Bcl-2-expression in Dys-regulated Distribution of T and B Lymphocytes in Aged Mice
Yongxin Zhang, Monica Zhang, Ying Wang, Lin Liu, Carolyn Sweeney, Lifang Tian and Innocent N Mbawuike
Research Article: J Clin Cell Immunol 2016, 7: 473
DOI: 10.4172/2155-9899.1000473
Next-Generation Sequencing Confirmation of Real-Time RT-PCR False Positive Influenza-A Virus Detection in Waterfowl and Swine Swab Samples
Lu H, Yi Tang, Lin Lin and David R Wolfgang
Research Article: Next Generat Sequenc & Applic 2016, 134
DOI: 10.4172/2469-9853.1000134
Selective Catalytic Reduction of NOx over Fe/TiO2 Prepared by F127- Template Method at Mid-Temperature
Yulin Li, Xiaojin Han, Yaoping Guo, Yaqin Hou, Zhanggen Huang and Qixiong Hou
Research Article: J Environ Anal Chem
DOI: 10.4172/2380-2391.1000185
Rats Metabolic Responses to Chronic Intervention with Cantonese Herbal Tea
Lin Li
Research Article: Metabolomics 2016, 6:178
DOI: 10.4172/2153-0769.1000178
Will Dengue Virus Infection Endanger Blood Safety?
Haiyan Ye, Shilin Li and Limin Chen
Editorial: J Antivir Antiretrovir 2016, 8:e129
DOI: 10.4172/jaa.1000e129
Molecular Characteristics of the N Gene of the Chicken Embryo Cell- Adapted Rabies Virus Strain CTNCEC25
Shimao Zhu, Hui Li, Farui Luo, Linlin Liang, Caiping Guo
Research Article: J Vaccines Vaccin
Comparison of Methotrexate with Tripterygium wilfordii Hook F in the Management of Rheumatoid Arthritis
Jianguo Yuan, Haiyan Ye, Shilin Li and Limin Chen
Editorial: J Bioanal Biomed 2015
DOI: 10.4172/1948-593X.1000e132
The Expression Level of TGF-β1, TGF-β3 and VEGF in Transplanted Oral Mucosal and Cutaneous Wounds
Jiarong Liu, Jiajia Zhao, Shue Li, Lijuan Zhu, Ran Yu, Yinying Qu, XiaoDan Zheng, Lin Liu and Lili Chen
Research Article: Clin Microbiol 2015, 4: 198
DOI: 10.4172/2327-5073.1000198
Fabrication of Nanoparticles of Silymarin, Hesperetin and Glibenclamide by Evaporative Precipitation of Nanosuspension for Fast Dissolution
Kakran M, Sahoo GN, Lin Li
Research Article: Pharm Anal Acta 2015, 6: 326
DOI: 10.4172/2153-2435.1000326
Prevalence of Metabolic Syndrome and Overweight/Obesity among Chinese Women of Childbearing Age: A Cross-Sectional Epidemic Study
Xiaomiao Zhao, Renmin Ni, Yu Li, Lin Li, Jia Huang, Na Di, Ricardo Azziz and Dongzi Yang
Research Article: J Anesth Clin Res 2014, 5: 444
DOI: 10.4172/2155-6148.1000444
Is Interferon-Free Treatment for HCV Possible?
Shan Chen, Shilin Li, Bing Liu, Li Ma, and Limin Chen
Editorial: J Antivir Antiretrovir 2014, 6: e119
DOI: 10.4172/jaa.10000e119
MicroRNA and its Potential Use for the Treatment of Hepatitis C Virus Infection
Wendi Zhao, Xiaoqiong Duan, Yujia Li, Shilin Li, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2014, 6: e125
DOI: 10.4172/1948-593X.1000e125
The Effect of Hand Hygiene Promotion in a University Hospital in China
Li-Li Xiang , Duo-Shuang Xie , Rui Li2 , Xiang-Yun Fu , Hui-Fang Wang ,Qiao Hu , Qin-Qing Luo , Lei Wang, Rui-Ping Lai and Han-Lin Liao
Research Article: J Nurs Care 2014, 3:211
DOI: 10.4172/2167-1168.1000211
The Relationship between Micro Albuminuria and Plasma Homocysteine Level in Chinese Patients with Hypertension
Wenlin MA, Ruhui LIU, Lin LI, Weiqi SHI, Liang DENG, Yan JIN and Ming LUO
Research Article: J Hypertens 2013, 3: 175
DOI: 10.4172/2167-1095.1000175
Genetic Approaches Used To Manage Patients with Breast Cancer: Implications for Individualized Therapy and Translational Medicine
Jianqin Wu, Jianguo Yuan, Guojin Chen, Yujia Li, Shilin Li, Xiaoqiong Duan, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2014, 6: e126
DOI: 10.4172/1948-593X.1000e126
An Efficient Method for Velocity Calibration and Prediction of Microseismic Event Location Using very Fast Simulated Annealing
Jingyi Chen, Gaoming Li, Allyson Gajraj, Yang Xing, Yalin Li, Furong Wu and Chen Yin
Research Article: J Geol Geosci 2014, 3: 159
DOI: 10.4172/2329-6755.1000159
Upregulation of Autophagy by Angiotensin II Triggers Phenotypic Switching of Aortic Vascular Smooth Muscle Cells
Yangfeng Tang, Zilin Liao, Zhiyun Xu and Lin Han
Research Article: J Clin Exp Cardiolog 2014, 5:308
DOI: 10.4172/2155-9880.1000308
Risk of Osteonecrosis among Persons with Osteoarthritis of the Knee: Findings from the UK based General Practice Research Database
Susan Jick and Lin Li
Research Article: Orthopedic Muscul Sys 2014, S2:002
DOI: 10.4172/2161-0533.S2-002
Panax Notoginsenosides Attenuates Pleural Inflammation in Rabbit Model
Helin Zhang, Ruilin Liu, Hongle Yang, Zhichao Wang and Chenli Li
Research Article: Cell Mol Biol
Does the Emerging Bunyavirus that causes Severe Fever with Thrombocytopenia Syndrome Impact the Blood Safety in China?
Peibin Zeng, Li Ma, Shilin Li, Chunhui Yang, Yujia Li, Xiaoqiong Duan, Bing Liu, Shan Chen and Limin Chen
Editorial: J Antivir Antiretrovir 2013, 5: e115
DOI: 10.4172/jaa.1000e115
A Preliminary Study on Multivariate Prediction of Seizure Outcome after Epilepsy Surgery
Jing Zhang, Hui Chen, Weifang Liu, Qingzhu Liu, Shanshan Mei and Yunlin Li
Research Article: OMICS J Radiol 2014, 3: 156
DOI: 10.4172/2167-7964.1000156
Correlations between Soluble Sugar and Phenol Contents in Leaves and Pear Scab Resistance
Yanbin Hua, Huangping Guo, Xin-Gen Zhou, Xiao Li, Sheng Yang, Yuqin Song, Ning Ma, Chenbo Chai, Xin Qiao and Liulin Li
Research Article: J Plant Pathol Microbiol 2014, 5: 213
DOI: 10.4172/2157-7471.1000213
Sentinel Lymph Node Biopsy in Papillary Thyroid Carcinoma
Dan-Gui Yan, Bin Zhang, Lin Liu, Li-Juan Niu, Chang-Ming An, Zheng-Jiang Li, Zhen-Gang Xu and Ping-Zhang Tang
Research Article: Thyroid Disorders Ther 2014, 3:140
DOI: 10.4172/2167-7948.1000140
Last Line to Secure Transfusion Safety: Pathogen Inactivation/Reduction Methods in Blood Products-Current Approaches and Perspectives
Chunhui Yang, Peibin Zeng, Yujia Li, Shilin Li, Xiaoqiong Duan, Hong Yang, and Limin Chen
Short Communication: J Antivir Antiretrovir 2013, 5: 137
DOI: 10.4172/jaa.1000077
Host Factors to Predict Treatment Response in HCV Patients: Implications for Individualized Therapy and Translational Medicine for HCV Management
Li Yuan, Jianguo Yuan, Yujia Li, Shilin Li, Xiaoqiong Duan, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2013, 5: e121
DOI: 10.4172/1948-593X.1000e121
Interventions to Improve CPAP Adherence and Outcomes: Role of Theory and Behavioral Change Techniques
Carl Stepnowsky, Tania Zamora, Christine Edwards, Lin Liu and Zia Agha
Research Article: J Sleep Disord Ther 2013, 2:133
DOI: 10.4172/2167-0277.1000133
Identification of a Location at Chromosome 19p in a Big Chinese Family with Charcot-Marie-Tooth Disease
Fei-Feng Li, Xu-dong Wang, Min-wei Zhu, Hui-wen Xiao, Quan Yang, Xin Shao, Hong-lin Feng, Zhi-Guo Lin and Shu-Lin Liu
Research Article: J Mol Biomark Diagn 2013, 4: 144
DOI: 10.4172/2155-9929.1000144
Detection of BRAF V600E Mutation in Langerhans Cell Histiocytosis Using High-resolution Melting Analysis in Decalcified, Paraffin-embedded Tissue
Bin Fu, Zhongqing Wang, Xiaolin Li, Sa A Wang and Zhuang Zuo
Short Communication: J Leuk 2013, 1: 101
DOI: 10.4172/2329-6917.1000101
Modulating Innate Immune Response to Combat Viral Infections-Use HCV as an Example
Yujia Li, shilin Li, Xiaoqiong Duan, Bing Liu, Peibin Zeng, Chunhui Yang and Limin Chen
Editorial: J Antivir Antiretrovir 2013, 5: e107
DOI: 10.4172/jaa.1000e107
NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis
Kiranmai Gumireddy, Anping Li, Lili Cao, Jinchun Yan, Lin Liu, Xiaowei Xu, Christopher Pazoles and Qihong Huang
Research Article: J Carcinog Mutagen 2013, S7- 002
DOI: 10.4172/2157-2518.S7-002
High-throughput Gene Expression Profiling: Its Application in Studying Transfusion-Transmitted Infections
Bing Liu, Shilin Li, Yujia Li, Xiaoqiong Duan and Limin Chen
Editorial: J Bioanal Biomed 2013, 5: e111
DOI: 10.4172/1948-593X.1000e111
Genome-wide Gene Expression Profiling: An Excellent Tool to Study Virus- Host Interactions
Limin Chen, Shilin Li, Yujia Li, Xiaoqiong Duan and Ian McGilvray
Editorial: J Biochip Tissue Chip 2012, 2:e118
DOI: 10.4172/2153-0777.1000e118
New Endoscopic Diagnosis and Treatment Options for Early Esophageal Cancer
Quan-Lin Li, Yun-Shi Zhong, Wei-Feng Chen, Meng-Jiang He, Ping-Hong Zhou and Li-Qing Yao
Review Article: J Gastrointest Dig Syst 2012, 2: 108
DOI: 10.4172/2161-069X.1000108
Risk Factors for Delayed Neuropsychiatric Sequelae in Carbon Monoxide Poisoning: Ten Years' Experience in a Pediatric Emergency Department
Mei-Hua Hu, Jing-Long Huang, Kuang-Lin Lin, Go-Shine Huang, Huei-Shyong Wang, Ming-Liang Chou, Po-Cheng Hung and Chang-Teng Wu
Research Article: J Clin Toxicol 2012, 2: 124
DOI: 10.4172/2161-0495.1000124
Targeting a Neutralizing Epitope of HIV Envelope Gp120 by Immune Complex Vaccine
Rajnish Kumar, Maria Luisa Visciano, Hualin Li and Catarina Hioe
Review Article: J AIDS Clin Res 2012, S8: 002
DOI: 10.4172/2155-6113.S8-002
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