alexa Editor - Lin Li | University of Texas at El Paso | 18719
ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
Open Access

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Lin Li

Lin Li
Lin Li
University of Texas at El Paso
United States


Education and work experience:
•Research Associate (Biophysics), Clemson University, 2013-now
•Post Doct (Biophysics), Clemson University, 2011-2013
•Ph.D. (Biophysics), Huazhong University of Science and Technology, 2005-2011
Research experience:
DelPhi Development: DelPhi is a widely used Poisson Boltzmann Equation solver. I have developed a Gaussian smooth method to DelPhi software, which is used to model the inhomogeneous dielectric properties of macromolecules. This method has been proved to be more accurate than the traditional 2-dielectric constant methods.

MEMPOT: A Membrane Potential (MEMPOT) tool is developed and implemented into DelPhi program. Using this MEMPOT tool, one can easily calculate the electrostatic potential distribution across the membrane.

ASPDock: He have developed a docking algorithm (ASPDock) to calculate binding free energy of protein complexes, which improves the accuracy of prediction effectively. Comparisons with other state-of-the-art docking algorithms showed that ASP score indeed gives higher success rate than the pure shape complementarity score of FTDock.

SRM: He also developed a Softly Restricting Method (SRM), which utilizes the unreliable binding site information to enhance success rate of docking. It only reduces hit count number and success rate slightly if the predicted information is completely wrong. However, when the predicted information is correct or partially correct, SRM increases the hit count number and success rate significantly.

CAPRI: Using ASPDock and Softly Restricting Method, his team has participated in two rounds of Critical Assessment of PRediction of Interactions (CAPRI). We got high-quality hits for T40 and T41 and the best LRMSD were 2.35 Å and 1.41 Å, respectively.
2001-2002: HUST Scholarship
2002-2003: National Scholarship by Chinese Government
Skills and Software
Programming language: Fortran/C/C++/Bash/Matlab
Molecular Simulatons: DelPhi/Tinker /NAMD
Protein-protein docking: ASPDock/SRM/FTDock/ZDOCK/GRAMM
Graphic: Chimera/PyMOL/Photoshop/Flash
Homology Modeling: SWISS-MODEL/I-TASSER

Research Interest

1.Protein electrostatic calculations ;
2.Molecular dynamic simulations;
3.Protein-protein interactions, Protein-RNA/DNA interactions, Protein-ligand docking;
4.Structure, function, chemistry, and in vivo modification and processing of proteins, nucleic acids, and other biologically important macromolecules;
5.Computational method for protein/DNA/RNA simulations.



Global Speakers in the subject

Global Experts in the subject


A to Z: Current Spinal Cord Injury Rehabilitation

Human Health Risk Levels and Distribution of PAHs in Soil Environment of a Coking Chemical Plant Located in Beijing, China

Jony Sieman, Mohammad Yusof Ibrahim and Constance Sat Lin Liew
: Int J Phys Med Rehabil 2018, 6: 485
DOI: 10.4172/2329-9096.1000485

High Throughput Detection Methods for Multiplex Mycotoxins

Jianli Jia, Haibin He, Zihao Wang, Shenwei Zhao, Linying Me, Jialin Liu, Shihai Zhang, Cunzhen Liang and Yinghua Zhang
Research Article: J Bioremediat Biodegrad 8: 407
DOI: 10.4172/2155-6199.1000407

BTG1 Low Expression in Pancreatic Ductal Adenocarcinoma is Associated with a Poorer Prognosis

Jianlin Li, Yang Deng, Yan Liu, Zhi Ding, Yichen Li, Yanhao Jin, Xuerui Zhu, Tingting Cai, Tiesong Zheng and Wei Li
Review Article: Toxicol Open Access 2017, 3:131
DOI: 10.4172/2476-2067.1000131

Change in Bank Equity Stakes before Merger Completion

Yufang Huang, Jiawei Zheng, Ting Tan, Li Song, Shanshan Huang, Yan Zhang, Lin Lin, Jingnan Liu, Peichan Zheng, Xiong Chen, Xi Chen and Xuenong Ouyang
Research Article: Diagn Pathol Open 2017, 1: 126
DOI: 10.4172/2476-2024.1000126

Differences, Correlation of Compositions, Taste and Texture Characteristics of Rice from Heilongjiang China

Paitoon Chetthamrongchai, Lin Lin, Hsaio-Fen Hsiao and Yu-LunHuang
Research Article: J Account Mark 2017, 6:222
DOI: 10.4172/2168-9601.1000222

Bcl-2-expression in Dys-regulated Distribution of T and B Lymphocytes in Aged Mice

Fenglian Chen, Chunhua Yang, Linlin Liu, Tianyi Liu, Yang Wang, Lichao Wang, Yanguo Shi and Osvaldo H Campanella
Research Article: J Rice Res 2016, 5: 178
DOI: 10.4172/2375-4338.1000178

Selective Catalytic Reduction of NOx over Fe/TiO2 Prepared by F127- Template Method at Mid-Temperature

Yongxin Zhang, Monica Zhang, Ying Wang, Lin Liu, Carolyn Sweeney, Lifang Tian and Innocent N Mbawuike
Research Article: J Clin Cell Immunol 2016, 7: 473
DOI: 10.4172/2155-9899.1000473

Rats’ Metabolic Responses to Chronic Intervention with Cantonese Herbal Tea

Yulin Li, Xiaojin Han, Yaoping Guo, Yaqin Hou, Zhanggen Huang and Qixiong Hou
Research Article: J Environ Anal Chem 2016, 3: 185
DOI: 10.4172/2380-2391.1000185

Comparison of Methotrexate with Tripterygium wilfordii Hook F in the Management of Rheumatoid Arthritis

Rong You, Liang Yin, Yanqing Guan and Lin Li
Research Article: Metabolomics 2016, 6:178
DOI: 10.4172/2153-0769.1000178

Prevalence of Metabolic Syndrome and Overweight/Obesity among Chinese Women of Childbearing Age: A Cross-Sectional Epidemic Study

Jianguo Yuan, Haiyan Ye, Shilin Li and Limin Chen
Editorial: J Bioanal Biomed 2015
DOI: 10.4172/1948-593X.1000e132

MicroRNA and its Potential Use for the Treatment of Hepatitis C Virus Infection

Xiaomiao Zhao, Renmin Ni, Yu Li, Lin Li, Jia Huang, Ricardo Azziz and Dongzi Yang
Research Article: J Anesth Clin Res 2014, 5: 444
DOI: 10.4172/2155-6148.1000444

The Effect of Hand Hygiene Promotion in a University Hospital in China

Wendi Zhao, Xiaoqiong Duan, Yujia Li, Shilin Li, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2014, 6: e125
DOI: 10.4172/1948-593X.1000e125

The Relationship between Micro Albuminuria and Plasma Homocysteine Level in Chinese Patients with Hypertension

Li-Li Xiang, Duo-Shuang Xie, Rui Li, Xiang-Yun Fu, Hui-Fang Wang, Qiao Hu, Qin-Qing Luo, Lei Wang, Rui-Ping Lai and Han-Lin Liao
Research Article: J Nurs Care 2014, 3:211
DOI: 10.4172/2167-1168.1000211

Genetic Approaches Used To Manage Patients with Breast Cancer: Implications for Individualized Therapy and Translational Medicine

Wenlin MA, Ruhui LIU, Lin LI, Weiqi SHI, Liang DENG, Yan JIN and Ming LUO
Research Article: J Hypertens 2013, 3: 175
DOI: 10.4172/2167-1095.1000175

Upregulation of Autophagy by Angiotensin II Triggers Phenotypic Switching of Aortic Vascular Smooth Muscle Cells

Jianqin Wu, Jianguo Yuan, Guojin Chen, Yujia Li, Shilin Li, Xiaoqiong Duan, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2014, 6: e126
DOI: 10.4172/1948-593X.1000e126

Panax Notoginsenosides Attenuates Pleural Inflammation in Rabbit Model

Yangfeng Tang, Zilin Liao, Zhiyun Xu and Lin Han
Research Article: J Clin Exp Cardiolog 2014, 5:308
DOI: 10.4172/2155-9880.1000308

A Preliminary Study on Multivariate Prediction of Seizure Outcome after Epilepsy Surgery

Helin Zhang, Ruilin Liu, Hongle Yang, Zhichao Wang and Chenli Li
Research Article: Cell Mol Biol

Host Factors to Predict Treatment Response in HCV Patients: Implications for Individualized Therapy and Translational Medicine for HCV Management

Jing Zhang, Hui Chen, Weifang Liu, Qingzhu Liu, Shanshan Mei and Yunlin Li
Research Article: OMICS J Radiol 2014, 3: 156
DOI: 10.4172/2167-7964.1000156

Identification of a Location at Chromosome 19p in a Big Chinese Family with Charcot-Marie-Tooth Disease

Li Yuan, Jianguo Yuan, Yujia Li, Shilin Li, Xiaoqiong Duan, Bing Liu and Limin Chen
Editorial: J Bioanal Biomed 2013, 5: e121
DOI: 10.4172/1948-593X.1000e121

NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis

Fei-Feng Li, Xu-dong Wang, Min-wei Zhu, Hui-wen Xiao, Quan Yang, Xin Shao, Hong-lin Feng, Zhi-Guo Lin and Shu-Lin Liu
Research Article: J Mol Biomark Diagn 2013, 4: 144
DOI: 10.4172/2155-9929.1000144

High-throughput Gene Expression Profiling: Its Application in Studying Transfusion-Transmitted Infections

Kiranmai Gumireddy, Anping Li, Lili Cao, Jinchun Yan, Lin Liu, Xiaowei Xu, Christopher Pazoles and Qihong Huang
Research Article: J Carcinog Mutagen 2013, S7- 002
DOI: 10.4172/2157-2518.S7-002

Genome-wide Gene Expression Profiling: An Excellent Tool to Study Virus- Host Interactions

Bing Liu, Shilin Li, Yujia Li, Xiaoqiong Duan and Limin Chen
Editorial: J Bioanal Biomed 2013, 5: e111
DOI: 10.4172/1948-593X.1000e111

New Endoscopic Diagnosis and Treatment Options for Early Esophageal Cancer

Limin Chen, Shilin Li, Yujia Li, Xiaoqiong Duan and Ian McGilvray
Editorial: J Biochip Tissue Chip 2012, 2:e118
DOI: 10.4172/2153-0777.1000e118

Risk Factors for Delayed Neuropsychiatric Sequelae in Carbon Monoxide Poisoning: Ten Years' Experience in a Pediatric Emergency Department

Quan-Lin Li, Yun-Shi Zhong, Wei-Feng Chen, Meng-Jiang He, Ping-Hong Zhou and Li-Qing Yao
Review Article: J Gastrointest Dig Syst 2012, 2: 108
DOI: 10.4172/2161-069X.1000108

Targeting a Neutralizing Epitope of HIV Envelope Gp120 by Immune Complex Vaccine

Mei-Hua Hu, Jing-Long Huang, Kuang-Lin Lin, Go-Shine Huang, Huei-Shyong Wang, Ming-Liang Chou, Po-Cheng Hung and Chang-Teng Wu
Research Article: J Clin Toxicol 2012, 2: 124
DOI: 10.4172/2161-0495.1000124
Rajnish Kumar, Maria Luisa Visciano, Hualin Li and Catarina Hioe
Review Article: J AIDS Clin Res 2012, S8: 002
DOI: 10.4172/2155-6113.S8-002
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