alexa Editor - Lin Li | University of Texas at El Paso | 18719
ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
Open Access

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Lin Li

Lin Li
Lin Li
University of Texas at El Paso
United States


Education and work experience:
•Research Associate (Biophysics), Clemson University, 2013-now
•Post Doct (Biophysics), Clemson University, 2011-2013
•Ph.D. (Biophysics), Huazhong University of Science and Technology, 2005-2011
Research experience:
DelPhi Development: DelPhi is a widely used Poisson Boltzmann Equation solver. I have developed a Gaussian smooth method to DelPhi software, which is used to model the inhomogeneous dielectric properties of macromolecules. This method has been proved to be more accurate than the traditional 2-dielectric constant methods.

MEMPOT: A Membrane Potential (MEMPOT) tool is developed and implemented into DelPhi program. Using this MEMPOT tool, one can easily calculate the electrostatic potential distribution across the membrane.

ASPDock: He have developed a docking algorithm (ASPDock) to calculate binding free energy of protein complexes, which improves the accuracy of prediction effectively. Comparisons with other state-of-the-art docking algorithms showed that ASP score indeed gives higher success rate than the pure shape complementarity score of FTDock.

SRM: He also developed a Softly Restricting Method (SRM), which utilizes the unreliable binding site information to enhance success rate of docking. It only reduces hit count number and success rate slightly if the predicted information is completely wrong. However, when the predicted information is correct or partially correct, SRM increases the hit count number and success rate significantly.

CAPRI: Using ASPDock and Softly Restricting Method, his team has participated in two rounds of Critical Assessment of PRediction of Interactions (CAPRI). We got high-quality hits for T40 and T41 and the best LRMSD were 2.35 Å and 1.41 Å, respectively.
2001-2002: HUST Scholarship
2002-2003: National Scholarship by Chinese Government
Skills and Software
Programming language: Fortran/C/C++/Bash/Matlab
Molecular Simulatons: DelPhi/Tinker /NAMD
Protein-protein docking: ASPDock/SRM/FTDock/ZDOCK/GRAMM
Graphic: Chimera/PyMOL/Photoshop/Flash
Homology Modeling: SWISS-MODEL/I-TASSER

Research Interest

1.Protein electrostatic calculations ;
2.Molecular dynamic simulations;
3.Protein-protein interactions, Protein-RNA/DNA interactions, Protein-ligand docking;
4.Structure, function, chemistry, and in vivo modification and processing of proteins, nucleic acids, and other biologically important macromolecules;
5.Computational method for protein/DNA/RNA simulations.



Global Speakers in the subject

Global Experts in the subject


Human Health Risk Levels and Distribution of PAHs in Soil Environment of a Coking Chemical Plant Located in Beijing, China

High Throughput Detection Methods for Multiplex Mycotoxins

Jianli Jia, Haibin He, Zihao Wang, Shenwei Zhao, Linying Me, Jialin Liu, Shihai Zhang, Cunzhen Liang and Yinghua Zhang
Research Article: J Bioremediat Biodegrad 8: 407
DOI: 10.4172/2155-6199.1000407

BTG1 Low Expression in Pancreatic Ductal Adenocarcinoma is Associated with a Poorer Prognosis

Jianlin Li, Yang Deng, Yan Liu, Zhi Ding, Yichen Li, Yanhao Jin, Xuerui Zhu, Tingting Cai, Tiesong Zheng and Wei Li
Review Article: Toxicol Open Access 2017, 3:131
DOI: 10.4172/2476-2067.1000131

Differences, Correlation of Compositions, Taste and Texture Characteristics of Rice from Heilongjiang China

Yufang Huang, Jiawei Zheng, Ting Tan, Li Song, Shanshan Huang, Yan Zhang, Lin Lin, Jingnan Liu, Peichan Zheng, Xiong Chen, Xi Chen and Xuenong Ouyang
Research Article: Diagn Pathol Open 2017, 1: 126
DOI: 10.4172/2476-2024.1000126

Panax Notoginsenosides Attenuates Pleural Inflammation in Rabbit Model

Fenglian Chen, Chunhua Yang, Linlin Liu, Tianyi Liu, Yang Wang, Lichao Wang, Yanguo Shi and Osvaldo H Campanella
Research Article: J Rice Res 2016, 5: 178
DOI: 10.4172/2375-4338.1000178

A Preliminary Study on Multivariate Prediction of Seizure Outcome after Epilepsy Surgery

Helin Zhang, Ruilin Liu, Hongle Yang, Zhichao Wang and Chenli Li
Research Article: Cell Mol Biol

Genome-wide Gene Expression Profiling: An Excellent Tool to Study Virus- Host Interactions

Jing Zhang, Hui Chen, Weifang Liu, Qingzhu Liu, Shanshan Mei and Yunlin Li
Research Article: OMICS J Radiol 2014, 3: 156
DOI: 10.4172/2167-7964.1000156

New Endoscopic Diagnosis and Treatment Options for Early Esophageal Cancer

Limin Chen, Shilin Li, Yujia Li, Xiaoqiong Duan and Ian McGilvray
Editorial: J Biochip Tissue Chip 2012, 2:e118
DOI: 10.4172/2153-0777.1000e118
Quan-Lin Li, Yun-Shi Zhong, Wei-Feng Chen, Meng-Jiang He, Ping-Hong Zhou and Li-Qing Yao
Review Article: J Gastrointest Dig Syst 2012, 2: 108
DOI: 10.4172/2161-069X.1000108