alexa Arg72pro POLYMORPHISM OF Tp53 GENE IS RELATED TO CARDIOVASCULAR RISK FACTORS AMONG CROATIAN SENESCENT MEN
ISSN: 2161-0711

Journal of Community Medicine & Health Education
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd World Congress on Public Health & Nutrition
March 22-23, 2017 | Rome, Italy

Petra Krajacic, Tatjana Skaric-Juric, Zeljka Tomas, Matea Zajc Petranovic and Nina Smolej Narancic
Institute for Anthropological Research, Croatia
Posters & Accepted Abstracts: J Community Med Health Educ
DOI: 10.4172/2161-0711.C1.025
Abstract
The p53 tumor suppressor protein, often termed the genome’s guardian, has a critical role in cell cycle, apoptosis, cell senescence, DNA repair and metabolism. Animal and human studies have identified TP53 gene as one of the most important candidate genes involved in longevity. Here, we investigated the associations of Arg72Pro polymorphism of TP53 gene with indicators of biological age in 324 people aged 85+ yrs. Univariate and multivariate analyses of wide spectrum of variables associated with health status included noninvasive biometric measurements, biochemical blood tests and self-rated health. In univariate analyses Arg/Arg was related with higher body mass (skinfold thickness, upper arm and waist circumferences) and with higher fasting blood glucose. T-test, ANOVA/PostHoc test results showed a significant positive association of Arg/Arg genotype with anthropometric nutritional status variables as well as with fasting glucose level (cardiovascular risk factors) in elderly men but not in women. Sex-specific principal component analysis encompassing 40 variables extracted four significant factors, among which the first factor represented body mass and composition while the second one represented general health. Although the two factors had almost identical structure in both sexes, the t-test (p = 0.031), ANOVA (p = 0.046) and PostHoc test (p=0.018) revealed significant association of Arg72Pro polymorphism only with the factor of general health in men, indicating that Arg/Arg was the risk and Arg/Pro was the protective genotype. Namely, Arg/Pro heterozygote carriers had better scores in personal independence, motility and self-rated health, suffered less from chronic and acute illness and used fewer medications. We suggest that further research should also be directed towards the investigation of gender specific influence of TP53 gene on different health-related traits. In conclusion, our results indicate the role of Arg72Pro polymorphism in health-related traits in men of very old age, but its role in longevity remains to be elucidated.
Biography

Petra Krajacic is Ph.D. student at Faculty of science (Department of Biology, Zagreb University, Croatia). In her dissertation she conducted an association study of four most important polymorphisms of longevity genes (p53, IL-6, TNF, SIRT1) and diverse phenotypic traits, like motility, independence, life satisfaction and the presence of age- related disease, of 325 very old age people (85+). This research is a part of a Complex traits variation and health in children, adults and centenarians project founded by the Ministry of Science, Education and Sports.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords