Journal of Community Medicine & Health Education
Open Access

Abstract

This study aimed to investigate the effect of Beta vulgaris var. cicla and Sonchus oleraceus leaves on impaired liver function of rats injected with carbon tetrachloride (CCl4). Chemical composition and natural phytochemicals in used plants were determined. Thirty six adult albino rats each weighing 155±5 g B.W% was used. The tested plants were given as a percent of 5 and 10 from the basal diet. Beta vulgaris var. cicla leaves was higher in crude protein, ash, carbohydrates and phytochemicals content than Sonchus oleraceus leaves. Serum liver functions (AST, ALT, ALP), kidney functions (Urea, Creatinine and Uric Acid), F.I, F.E.R, B.W.G% of rats and histopathological changes of liver and kidney were examined. The results indicated that rats treated with CCl4 group recorded significantly increasing in the activity levels of all biomarker liver enzymes (AST, ALT and ALP) when compared with the control group. Addition of tested plant leaves, induced significant improvement in all liver and kidney functions, also CCl4 treated group had histopathological changes in liver and kidney through degeneration hyperemia, inflammatory reaction. The post-treatment of tested plant leaves with CCl4 lead to protect some of the previous histopathological changes. It could be concluded that the tested plant leaves had hepatoprotective effect against CCl4 –induced hepatotoxicity in liver , liver and kidney functions and its histopathological changes, so it could be recommended that those tested plant leaves by a moderate amount to be included in our daily diets.

Biography

Abeer N Abdel Rahman completed his PhD Degree in Nutrition and Food Science from Minoufiya University.

Email: Abeer.Nazeih37@Yahoo.com