Introduction: Human body needs some of essential metal for synthesis and functioning of red blood cells (RBC). However,
RBC is the main target for many toxic metals which may lead to anemia. After sharply decreasing in many toxic metal exposures
during the past decades, it is essential to study these elements effect, at low-levels, on pregnancy outcomes.
Methods: To investigate the concentration of metals in pregnant women, we have conducted a longitudinal study from early
pregnancy to the delivery. Pregnant women (n=364) who referred to hospitals for prenatal care at the first trimester of pregnancy
were asked to participate in the survey. Maternal whole blood samples, one for each pregnancy trimesters (i.e., 3 times), and the
umbilical cord blood samples, at the time of delivery, were collected and subjected to ICP-MS analysis for measurement of metal
Results: The first trimester blood concentration of arsenic was significantly correlated with RBC counts in the first, second, and
third trimesters of pregnancy (r= 0.312, 0.424, and 0.183, respectively; p<0.05). Inversely, maternal blood level of molybdenum in
the first trimester of pregnancy was significantly correlated with decrease in RBC counts in the first, second, and third trimesters
(r= -0.182, -0.149, and -0.193, respectively; p<0.05). The study failed to find significant correlation between blood lead and
anemia in all trimesters at mean level of <5μg/dL.
Conclusions: The results of present study show that the first trimester of pregnancy blood arsenic may reduce and molybdenum
may induce the risk of anemia.
Mohsen Vigeh obtained Ph.D. degree in Social Medicine, the University of Tokyo, Japan, and completed medical doctorate course in Faculty of
Medicine, Tehran University, Iran. He had been working for Tehran University of Medical Sciences for several years and currently is scientific staff of
the National Institute of Occupational Safety and Health, Japan. He has collaboration with several local and overseas universities/institute and dose
peer review of some journals. Dr. Vigeh's research interest is ?reproductive toxicology? and ?urban air pollution?.
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