Effects Of Noise On Single Nucleotide Polymorphisms In Genes Related To Hypertension | 2843
ISSN: 2161-0711

Journal of Community Medicine & Health Education
Open Access

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Effects of noise on single nucleotide polymorphisms in genes related to hypertension

2nd International Conference and Exhibition on Occupational Health & Safety

Syed Kashif Nawaz and Shahida Hasnain

AcceptedAbstracts: J Community Med Health Educ

DOI: 10.4172/2161-0711.S1.016

Introduction: Present study discusses the effects of noise on association between hypertension and different genetic variants. Method: Genetic variations like ACE G2350A polymorphism, Ren G1051A polymorphism, AT1R A1166C polymorphism and ACE ID polymorphism were studied for the detection of any association between the polymorphisms and hypertension in 476 samples collected from sites with specific sound level ranges. Results: ACE ID genotype carriers were found on risk margin of hypertension only on exposure of high noise (OR: 1.958; 95% Confidence interval: 0.780- 4.914) or when whole data was analyzed without considering noise exposure (OR: 1.466; 95% CI: 0.805-2.671). Homozygous ACE 2350A carriers were also found on risk margin of hypertension only in normal sound exposed group (OR: 7.125; 95% CI: 1.959-25.90) or when whole data was analyzed without considering noise exposure (OR: 3.112; 95% CI: 1.373-7.054). AA carriers exposed to low noise were also vulnerable to develop hypertension but the risk value was at margin level (OR: 4.393; 95% CI: 0.967-19.95).
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