Effects Of Noise On Single Nucleotide Polymorphisms In Genes Related To Hypertension | 2843
Journal of Community Medicine & Health Education
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Introduction: Present study discusses the effects of noise on association between hypertension and different genetic variants.
Method: Genetic variations like ACE G2350A polymorphism, Ren G1051A polymorphism, AT1R A1166C polymorphism and
ACE ID polymorphism were studied for the detection of any association between the polymorphisms and hypertension in 476
samples collected from sites with specific sound level ranges.
Results: ACE ID genotype carriers were found on risk margin of hypertension only on exposure of high noise (OR: 1.958; 95%
Confidence interval: 0.780- 4.914) or when whole data was analyzed without considering noise exposure (OR: 1.466; 95% CI:
0.805-2.671). Homozygous ACE 2350A carriers were also found on risk margin of hypertension only in normal sound exposed
group (OR: 7.125; 95% CI: 1.959-25.90) or when whole data was analyzed without considering noise exposure (OR: 3.112; 95%
CI: 1.373-7.054). AA carriers exposed to low noise were also vulnerable to develop hypertension but the risk value was at margin
level (OR: 4.393; 95% CI: 0.967-19.95).
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals