Journal of Community Medicine & Health Education
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Introduction: Present study discusses the effects of noise on association between hypertension and different genetic variants.
Method: Genetic variations like ACE G2350A polymorphism, Ren G1051A polymorphism, AT1R A1166C polymorphism and
ACE ID polymorphism were studied for the detection of any association between the polymorphisms and hypertension in 476
samples collected from sites with specific sound level ranges.
Results: ACE ID genotype carriers were found on risk margin of hypertension only on exposure of high noise (OR: 1.958; 95%
Confidence interval: 0.780- 4.914) or when whole data was analyzed without considering noise exposure (OR: 1.466; 95% CI:
0.805-2.671). Homozygous ACE 2350A carriers were also found on risk margin of hypertension only in normal sound exposed
group (OR: 7.125; 95% CI: 1.959-25.90) or when whole data was analyzed without considering noise exposure (OR: 3.112; 95%
CI: 1.373-7.054). AA carriers exposed to low noise were also vulnerable to develop hypertension but the risk value was at margin
level (OR: 4.393; 95% CI: 0.967-19.95).
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