Expression And Role Of Resistin And PPAR-? (Peroxisome Proliferator-Activated Receptor-?) Receptor In Porcine Ovarian Follicles | 3182
Journal of Community Medicine & Health Education
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Adipose tissue is not only as a reservoir of energy-rich molecules but also as height specialized, active endocrine organ
directly involved in the control of metabolism and reproductive function through a large number of secreted cytokines and
hormones including resistin. Resistin gene expression is detected in adipocytes, and its levels are increased in morbidly obese
humans compared with lean control subjects. Transcription factor PPAR-γ, which is specific to adipocytes, has been shown to be
important in ovarian function and resistin expression also. Using RT-PCR, immunoblotting and ELISA method we measurement
expression and direct in vitro effect of resistin and PPAR- γ receptor on steroid hormone secretion and steroid enzyme expression
in porcine ovary. In the pig ovaries collected from prepubertal animals resistin expression was increased during follicular
development. Concentration of resistin increased during follicular growth, with the highest level in large follicles, and it was
correlated with estradiol levels in follicular fluid. Additionally, resistin can modulate ovarian cells steroidogenesis by effect on
androgen production. Expression of PPAR-γ receptor was also detected in ovarian follicles, with maximum in large ovarian
follicles collected from normal estrus cycle animals. Resistin is new adipokine which was expressed in ovary and control female
reproduction. However, the mechanism of resistin action in the ovary will not be able to fully understand until its receptor will
not be identified.
Supported by the Polish Committee for Scientific Research as a project Iuventus Plus Programme 0343/PO1/2010 and part
of 0447/IP1/2011/71 from 2011- 2014 Poland.
Dr. Agnieszka Rak-Mardyła is an Assistant Professor at Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian
University in Cracow, Poland.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals