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Expression And Significance Of Death Receptors In Alveolar Macrophages From Silicosis Patients | 2782
Journal of Community Medicine & Health Education
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Objective: To explore the expression of death receptors in alveolar macrophages from silicosis patients were detected and the
relationship between death receptors level and lung fibrosis.
Methods: 48 male silicosis patients and 13 male observers treated by whole lung lavage were choosen as subjects. 13 male health
people with normal lung X-ray photograph were selected as the control group. The alveolar macrophags (AM) were collected,
purified and incubated at 37?C for 24 hours. After that three kinds of soluble death receptors (sDR) were determined by ELISA,
while the membrane-bound death receptors (mDR) were detected by Western blot. The relationship between DR and silica
exposure related factors was analyzed.
Results: The grayscale of mDR in those exposed to silica was thicker than those of controls, and increased with the lung fibrosis
progression. The mDR level in silicosis patients was higher than those of the control group and observers P<0.05.
Conclusion: The upregulated mDR and downregulated sDR induced by silica in human AM may play important role in
the development and progression of silicosis, death receptor pathway activation may be the important mechanism of silica
Keywords: Death receptor; Silicosis; Apoptosis related factor; Tumor necrosis factor receptor, TNF related apoptosis inducing
Sanqiao Yao, is a Professor, Ph.D., Director of Department of Preventive Medicine, School of Public Health, Hebei United University, Member of
standing committee of Radical Preventive Medicine Society, China Preventive Medical Association, Member of Occupational Medicine Society,
China Coal Labor Protection Association & Occupational Psychology and Stress Group, China Occupational Health and Medicine Association;
Member of the editorial board of Chinese Preventive Medicine and Reviewer of China Occupational Medicine, Toxicology Letter, Environ Monitoring
& Assessment and Biomedicine & Environ Science.
**This work was supported by the Natural Science Foundation of China (30671741), the Pneumoconiosis Treatment Foundation for China Coal
Miners (2005-03), and the Science and Technology Support Program of Hebei Province (09276196D).
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