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Rebound Weight Gain Worsen The Experimental Non-alcoholic Fatty Liver Diseasein Rat Model | 41457
ISSN: 2161-0711
Journal of Community Medicine & Health Education
Open Access
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Background: The prevalence of obesity is increasing worldwide and recurrent attempts for losing weight are very common.
Diet cycling predisposes to health hazards including non-alcoholic fatty liver disease (NAFLD). This study aimed at evaluating
the effect of diet cycling on the course of NAFLD.
Materials and methods: Male albino Sprague-Dawly rats were used in the study, 24 rats were kept on standard pellet animal
diet to serve as control group and 24 rats were fed high fat diet (HFD) for sixteen weeks. Cycling diet group were fed HFD
for eight weeks to induce NAFLD, and then shifted to normal caloric diet for four weeks, and then rebound weight gain
is allowed by subjecting rats to another four weeks for HFD. Every time interval 8 rats were sacrificed and evaluated for
body mass index, liver index, lipid profile, liver enzymes, HOMA-IR index, free fatty acids, TNF-α, IL-6, TGF-β. Oxidative
stress enzymes were also measured. Liver histopathology and α-SMA immunoreactivity were evaluated. Results Cycling diet
group showed significant increase in inflammatory markers most notably TNF-α with concomitant significant decrease in
glutathione reductase levels. Significant increase in BMI, Liver index and other parameters was obvious. More fatty infiltration
was noted in cycling group with more inflammatory infiltration.
Conclusion: Cycling diet had a negative influence on NAFLD and interfered with normal liver function. Cycling diet caused
more fatty infiltration and more inflammation than the continuous HFD. Continuous HFD and cycling diet shared the same
fibrosis stage. These results suggest that rebound weight gain affect the course of NAFD negatively.