Journal of Community Medicine & Health Education
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Background: At present, the exact association between psychological stress and polymorphisms of HSP70 gene is not clear, and
no study assessing the relationships between stress and polymorphisms of HSP70 gene and T2DM in Moslem and Han people in
Ningxia, China has been reported. This study is designed to explore the potential associations among work?related stress, HSP70
gene polymorphism and protein expression, and the risk of T2DM.
Methods: We applied occupational Stress Indicator (OSI), PCR-PFLP technique and ELISA respectively to detect work-related
stress level, the genotype and allele frequency of HSP70-1 (+190G/C), HSP70-2 (+1267A/G) and HSP70-hom (+2437T/C), and
protein expression level in serum in 201 unrelated Moslem and Han patients with T2DM and 471 healthy control.
Results: We found the high stress level, G/G genotype and G allele of 1267 HSP70-2, and high expression of HSP70 were associated
with significantly higher risk of T2DM when compared with low stress level (ORafter=2.406, P=0.000, 95%CI=1.535∼3.773),
A/A genotype (ORafter=2.543, P=0.000, 95%CI=1.554∼4.163), A allele (ORafter=1.537, P=0.000, 95%CI=1.213~1.946), and low
expression (ORafter=1.780, P=0.006, 95%CI=1.176∼2.694) before and after adjusting age, gender and race. But no associations
were observed between the polymorphisms of HSP70 gene with the susceptibility of stress, and T2DM between Moslem and
Han. The risk of high expression in G/G genotype of 1267 HSP70-2 and Moslem was higher than in A/A (ORafter=1.657, P=0.014,
95%CI=1.107~2.478) before and after adjusting age, gender and race and Han (ORafter=2.178, P=0.009, 95%CI=1.211~3.916)
before and after adjusting age and gender.
Conclusions: High stress level, the homozygous G/G genotype and G allele of 1267 HSP70-2 and high expression of HSP70
may enhance the risk of T2DM remarkably. The genotypes of 1267 HSP70-2 may affect the expression level of HSP70. High
expression in Moslem may explain partially the reason that T2DM was more common in Moslem than in Han group in Ningxia
(our previous study found).
Key words: work-related stress; type 2 diabetes; HSP70; gene polymorphism; expression level; relative risk
Hui Song is a senior professor in Ningxia Medical University, and also a member of occupational psychology and stress group of China Institute
of Occupational Health and Occupational Medicine and an expert of chemical toxicity appraisal in China Health Ministry. She had ever worked in
McMaster University in Canada as a visiting scholar, and is invited to Japan for academic exchange and cooperation researches for three times. She
has published more than 25 papers in reputed journals in China. In the recent years, she takes charge of research projects including nation natural
science fund (NSFC), international cooperation of Japan-China, major project of China Education Ministry, and so on.
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