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Chi-Yu Gregory Lee is a Professor in the Department of Obstetrics and Gynaecology, University of British Columbia, Columbia, Canada.
Research and Development of Antibody-Based Anti-Cancer Drugs. RP215 monoclonal antibody was shown to recognize specifically a carbohydrate-associated epitope located on the variable regions of cancer cell expressed immunoglobulins, designated in general as CA215.Structural elucidation of carbohydrate-associated epitope in CA215 which is recognized by RP215 monoclonal antibody (Mab). Humanizations of RP215 Mab for preclinical studies. Generations of Rat anti-idiotype Mabs as candidates for the development of anti-cancer vaccines in humans. Establishment of an Anti-GnRH receptor Mab, GHR106, as a substitute of short-acting GnRH analogs for antibody-based anti-cancer drugs, as well as preclinical studies. Elucidation of mechanisms of action for RP215 and GHR106 as antibody-based anti-cancer drugs. Elucidation of a carbohydrate-associated epitope recognized by RP215 monoclonal antibodies.
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