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James M. Mathew, PhD. is an Associate Professor in the Departments of Surgery and Microbiology-Immunology, and the Director of Immune Monitoring Core at the Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago. His research for the past 27 years has been in the areas of immune responsiveness and tolerance in clinical organ transplantation. These studies have resulted in more than 230 peer reviewed publications. The major thrust of these has been on the immunological effects of donor bone marrow cell and donor hematopoietic stem cell infusions in organ transplant patients using in vitro and ex vivo culture systems. One specific observation was that the use of an array of assays for donor specific unresponsiveness could possibly identify potentially tolerant recipients who may be candidates for immunosuppressive drug withdrawal. Recent studies have also assessed the role of CD4+CD127-CD25HighFoxP3+ regulatory T cells as potential tolerance inducers in kidney and liver transplant patients, as well as the differential susceptibility these cells to clinically used immunosuppressive drugs. More recently, he has developed the technology to expand antigen-specific regulatory T cells with a view to using them clinically to induce donor specific tolerance.
Clinical Trial Methodology, Immune Regulation, Immunology; Infectious Diseases-viral, Liver disease, pathobiology, Stem Cells, Translational Research, Transplantation
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