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The objective of the study was to evaluate the risk factors of Tuberculosis (TB) infection in some rural areas and
to take appropriate intervention to reduce the TB burden in some high-risk population group in China.
We have implemented a matched case control study in Danyang and Xiangtan County in 2012. The subjects were
selected from the new SS+ PTB cases whichwere diagnosed from January to June in 2012. Two community controls were
selected for each case in the same town, matched with gender, and age(+5). The standard questionnaire was used to investigate
the cases and controls for their social characteristics, behavior and lifestyle, pasthealth status, social economic condition,
household environment and health service utilization. The conditional logistic model has been utilized to analyze the risk
factors of tuberculosis.
The risk factors for TB are smoking, second-hand smoking, sleeping, BMI, BCG Vaccination, previous diabetes,
previous history of hypertension/coronary heart disease, close contact with TB patients, per capita living space, ventilation of
the bedroom, income etc. The odds ratio for the risk factors indicated by conditional logistic model due to smoking is (OR)
:9.99, 95% CI: 4.09-24.41, secondhand smoke daily (OR): 3.05, 95% CI: 1.48-6.30, BMI<18.5Kg/m
(OR): 7.32, 95% CI: 2.91-
18.41, previous diabetes(OR) : 7.71, 95% CI: 1.27-47.02, close contact with TB patients(OR): 3.15, 95% CI: 1.05-9.48, per-capita
(OR): 3.60, 95% CI: 1.77-7.33, previous hypertension/ coronary heart disease (OR): 0.14, 95% CI: 0.05-0.39,
and annual household income more than 50000 RMB Yuan (OR): 0.32, 95% CI: 0.14-0.76.
Our study shows that underweight and low-income populations are the high-risk groups and should be taken
for more intervention. Various factors like strengthening health education, modifying unhealthy lifestyle such as reducing the
usage of tobacco and regularly meeting the doctors will help to reduce the burden of TB in rural areas of China. This study was
supported by National Science and Technology Major Project-Communicable Diseases in China.
Wei Chen has got his PhD from Chinese Academy of Preventive Medicine in 2004, and engaged in the Chinese Tuberculosis Control and Prevention. He was
a visiting Scholar in UCLA from Sep. 2012 to June 2013. He is currently the Vice Director of the Department of surveillance, National Center for TB Control and
Prevention. He has taken up many research projects and published more than 20 papers in reputed journals.
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