Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Admixture Mapping And Its Application To Lupus Gene Identification In African-Americans | 12959
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Select your language of interest to view the total content in your interested language

Google Scholar citation report
Citations : 2284

Epidemiology: Open Access received 2284 citations as per Google Scholar report

Epidemiology: Open Access peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Genamics JournalSeek
  • SafetyLit
  • Access to Global Online Research in Agriculture (AGORA)
  • Centre for Agriculture and Biosciences International (CABI)
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • CABI full text
  • Cab direct
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Admixture mapping and its application to lupus gene identification in African-Americans

International Conference on Epidemiology and Evolutionary Genetics

Swapan K. Nath

Accepted Abstracts: Epidemiol

DOI: 10.4172/2161-1165.S1.004

A frican-Americans (AA) are at increased risk of systemic lupus erythematosus (SLE or lupus), an inflammatory autoimmune disease with strong genetic component, but the genetic basis of this risk increase is largely unknown. To identify causal variants in SLE, we performed admixture mapping followed by fine mapping in AA and European-Americans (EA). Through genome-wide admixture mapping in AA, we identified a strong SLE susceptibility locus at 2q22-24 (LOD=6.28) and the admixture peak is associated with the European ancestry that contributes ancestry risk ratio of ~1.5. Large-scale genotypic analysis on 19,726 individuals of African and European ancestry revealed three independently associated variants, including the previously known variant, within the IFIH1gene: an intronic variant, rs13023380 [P meta =5.20x10 -14 ; odds ratio, 95% confidence interval = 0.82 (0.78-0.87)], and two missense variants, rs1990760 (Ala946Thr) [P meta =3.08x10 -7 ; 0.88 (0.84-0.93)] and rs10930046 (Arg460His) [P dom =1.16x10 -8 ; 0.70 (0.62-0.79)]. We showed distinct functions of two coding SNPs including changes in gene expression and assigned function of the intronic SNP by EMSA, protein identification and in vitro protein binding assays. Both missense variants produced dramatic phenotypes changes in apoptosis and gene expression leading to inflammation. DNA carrying intronic risk allele of rs13023380 showed reduced binding efficiency to a cellular protein complex including NCL and Ku70/80, and showed reduced transcriptional activity in vivo . Thus in SLE patients, genetic susceptibility could create a biochemical imbalance that dysregulates NCL, Ku 70/80, or other nucleic acid regulatory proteins. This could promote antibody hypermutation and auto-antibody generation, further destabilizing the cellular network. SLE is commonly identified with an up-regulation of the interferon pathway. Together with molecular modeling, our results establish a distinct role for IFIH1 in apoptosis, inflammation and autoantibody interaction, and explain the molecular basis of these three risk alleles for SLE pathogenesis.
Swapan K Nath completed his M.Sc. from University of Calcutta, India in 1989 and later on did his Doctoral & Post doctoral studies at Indian Statistical Institute, Calcutta, India, 1995 and Case Western Reserve University, Cleveland, OH from 1995-2000 respectively. He is the recipient of many Honors and Awards as distinguished scientist as well as a researcher and the Ad hoc reviewer for 6 international Scientific Journals & a member of 3-4 scientific societies. Currently he is the Member, Arthritis & Clinical Immunology Research Program and Adjunct Associate Professor, Department of Pediatrics and Department of Pathology, University of Oklahoma Health Sciences Center, USA.