Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Association Of 5HTT Gene Polymorphism With Response To Treatment And Survival In Cancer; Can It Be A Prognostic Indicator? | 12918
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2284

Epidemiology: Open Access received 2284 citations as per Google Scholar report

Epidemiology: Open Access peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Genamics JournalSeek
  • SafetyLit
  • Access to Global Online Research in Agriculture (AGORA)
  • Centre for Agriculture and Biosciences International (CABI)
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • CABI full text
  • Cab direct
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Association of 5HTT gene polymorphism with response to treatment and survival in cancer; Can it be a prognostic indicator?

International Conference on Epidemiology and Evolutionary Genetics

Noha Awad

ScientificTracks Abstracts: Epidemiol

DOI: 10.4172/2161-1165.S1.002

C ancer patients with curable/controllable disease who deteriorate without an obvious clinically detectable cause have led researchers to investigate the relation between depression and cancer outcomes. Depression has been associated with unfavourable cancer treatment outcomes as decreased compliance, decreased desire for life-sustaining treatment and increased mortality. Lab studies demonstrated that neurotransmitters are capable of altering immune function whereas immune-derived mediators regulate neuroendocrine and autonomic outflow from the brain. Host cellular defenses against cancer involve immune mediated mechanisms that can be influenced by neurotransmitter activity. Polymorphisms of the 5-HTT gene explain why some individuals develop psychological morbidities on exposure to stressful life events while others exposed to the same conditions don't. This offers a screening criterion for identifying patients at risk for psychological morbidity that might be detrimental to their treatment outcome and may be used as a prognostic indicator and as a patient selection tool for comprehensive psychiatric care during cancer treatment. Aim: To study the role of 5HTT gene as a prognostic indicator in cancer. Method: A longitudinal observational study in which cancer outcomes are compared in two independent cohorts of cancer patients grouped by 5HTT genotype (patients with two long alleles versus those with at least one short allele). Results: Cox proportional hazards model showed a significant difference in progression-free survival between the long/long genotype group and the short/short genotype group after correction for age, cancer type and stage (p=0.031). The difference between the long/long genotype group and the short/long genotype group was not statistically significant. There was no statistically significant difference between the groups in objective tumour response rate at six months.
Noha Awad is a cancer epidemiologist who started her career as a clinical oncologist and completed her clinical training between Egypt and the UK obtaining her Ph.D. from University of Leeds and her MPH from University of Manchester. Since her return to Egypt, she has established the University's cancer epidemiology research centre and rolled out two independent research programs supported by the Egyptian Science and Technology Development Fund (STDF). She is currently lecturer of cancer epidemiology at the High Institute of Public Health and coordinator of the Egyptian Cancer Research Network.
Relevant Topics