CD55 Genetic Variations Increase The Disease Severity Of Pandemic H1N1 (2009) Influenza Infection | 17900
ISSN: 2161-1165
Epidemiology: Open Access
Open Access
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
P
andemic H1N1 2009 (H1N1pdm) influenza is commonly manifested as a mild infection but occasionally treated as a
severe pneumonia. Unlike seasonal influenza, people under 65 years of age were infected preferentially, with high rate of
severe infection and mortality in younger patients globally and in Hong Kong. Among these patients, about one third of the
severe and fatal cases do not have co-morbid conditions, implicating that inter-individual genetic variation may account for
the distinct disease severity of H1N1pdm infection. An initial small scale genome wide association study guided the selection
of
CD55
single nucleotide polymorphisms in 425 Chinese patients with severe (n=177) and mild (n=248) disease. Carriers
of rs2564978 genotype T/T were significantly associated with severe infection (OR 1.75, p=0.011) after adjusting the clinical
confounders. Allele-specific effect on
CD55
expression was examined and ascribed to a promoter indel variation rs3841376,
which was in perfect linkage disequilibrium with rs2564978. The promoter variant with deletion exhibited significantly lower
transcriptional activity. We further demonstrated that CD55 can protect respiratory epithelial cells from complement attack.
We also demonstrated that CD55 knockout mice are more susceptible to lethal infection of H1N1pdm. In conclusion, CD55
gene polymorphisms are associated with severe H1N1pdm infection. CD55 may exert a substantial impact on the disease
severity of H1N1pdm infection.
Biography
Jie Zhou has completed her PhD from The University of Hong Kong. After her Postdoctoral studies in UCSF, USA she is now a Research Assistant Professor in
Department of Microbiology at Hong Kong University.
Relevant Topics
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar