Evolution By Tumor Neofunctionalization And Phenomenon Of TSEEN Genes | 12936
Epidemiology: Open Access
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arlier hypothesis of possible evolutionary role of tumors was formulated. This hypothesis suggests that tumors supply evolving
multicellular organisms with extra cell masses for the expression of newly evolving genes. After expression of novel genes in
tumors cells, tumors differentiate in new directions and give rise to new cell types, tissues and organs.
In the lecture, the bulk of data supporting the positive evolutionary role of tumors will be reviewed, obtained both in the lab
of the author and from the literature sources.
The following issues will be addressed: the widespread occurrence of tumors in multicellular organisms; features of tumors
that could be used in evolution; the relationship of tumors to evo-devo; examples of recapitulation of some tumor features in
recently evolved organs; the types of tumors that might play the role in evolution; examples of tumors that have played the role
The discussion of experimental confirmation of nontrivial predictions of the hypothesis will include the analysis of
evolutionary novelty of tumor-specifically expressed EST sequences;
a human gene with possible microRNA function
expressed predominantly in tumors and originated in primates;
, a human gene of the recent
origin with predicted
highly tumor-specific expression profile; and the evolutionary novelty of human cancer/testis antigen genes.
The conclusion is made that expression of protogenes, evolutionarily young and/or novel genes in tumors might be a new
biological phenomenon, a phenomenon of TSEEN (Tumor Specifically Expressed, Evolutionarily New) genes, predicted by the
hypothesis of evolution by tumor neofunctionalization.
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