Finding Mutational Sites In Drug Resistant Strain Of Mycobacterium Tuberculosis | 17941
Epidemiology: Open Access
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is an acid-fast bacterium that is responsible for causing tuberculosis. The new strains that are
evolving with time are resistance to drugs currently being used for tuberculosis treatment. The study was focused on
locating mutational sites of a new strain,
, using next generation sequencing techniques.
genome assembly had been done to find out conserved and divergent regions of reference strains. The sequence data of the new
strain was derived from public database, analyzed and assembled using both
and mapping methods. The assembled
sequence compares reference genome followed by gene prediction and analysis. The newly found genome is aligned with
annotated reference genome to retrieve mutational sites in the new strain. The new strain shows several numbers of mutation
sites at or nearby exon regions that can cause resistance to drug treatment.
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