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ardiovascular disease is the leading cause of illness and death in women. Women appear to have greater resistance to
atherosclerosis in the pre menopausal years and this is attributed in part to an estrogen dependent increase in the basal
nitric oxide synthesis. Women in post menopausal years have estrogen deficiency due to the waning ovarian activity. Hormone
replacement therapy potentiates the release of endothelium derived relaxation factor, Nitric oxide and thus reduces the risk of
coronary artery disease in postmenopausal women. The study group included fifty postmenopausal women and the control
group included fifty healthy women with regular menses. Serum levels of nitric oxide end products (NOEP)were measured in the
control group and before and after hormone replacement therapy in the in the study group .Women in the study group were placed
on Hormone replacement therapy (HRT) for six months. Serum NOEP levels in the study group before hormone replacement
therapy (19.57 + 2.44) were significantly lower (p<0.001) than the control group (34.58 + 6.23). The serum NOEP levels increased
significantly (p<0.001) after hormone replacement therapy (29.97 + 3.82) in the study group. The rise was significantly (p<0.001)
in the hysterectomised post menopausal women (31.08 + 2.84).
Shilpika Saxena has completed her M.B.B.S. from Government Medical College, University of Rajasthan, India and M.D. from Armed Forces
Medical College, Pune University, India, residency at Armed Forces Medical College, Pune University, India. She is currently serving as the Assistant
Professor, Biochemistry in the Medical University of the Americas, Nevis.
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