alexa Inhibition Of The Orphan Nuclear Receptor Estrogen Related Receptor Alpha Sensitizes Breast Cancer Cells To DNMT Inhibitors | 66938
ISSN: 2572-4118

Breast Cancer: Current Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

5th World Congress on Breast Cancer
June 15-17, 2017 London, UK

Mathieu Vernier
McGill University, Canada
Posters & Accepted Abstracts: Breast Can Curr Res
DOI: 10.4172/2572-4118-C1-006
Abstract
Alterations in DNA methylation are implicated in the acquisition of malignant phenotype, and the use of epigenetic drugs is a promising strategy for anti-cancer therapy. In breast cancer, cell metabolism is tightly regulated by the oncogenic nuclear receptor estrogen-related receptor alpha (ERRa) and we wondered whether ERRa regulates SAM levels and DNA methylation. A gene signature designed to assess ERRa activity reveals that patients with high ERRa activity have a shorter free-disease survival. Interestingly, expression of the principal DNA methyltransferase DNMT1 follows the expression profile of ERRa gene signature. Further analysis of chromatin immunoprecipitation experiments followed by DNA sequencing (ChIPseq) of ERRa conducted in breast cancer cell lines showed that ERRa is located on the promoter of DNMT1 and many genes implicated in one carbon metabolism. Inhibition of ERRa reduced DNMT1 expression at the mRNA and protein levels and induced changes in SAM levels. Therefore, treatment of breast cancer cells with the ERRa inhibitor C29 highly sensitized these cells to the DNMTi. Surprisingly, inhibition of DNMT1 reduced protein levels of ERRa, unraveling the existence of a feedback loop. Further investigations on mouse models will be conducted to validate these results in vivo. We propose that patients with high ERRa activity would respond well to a combined treatment of ERRa and DNMT inhibitors.
Biography

Mathieu Vernier has completed his PhD from Montréal University and and is currently achieving his postdoctoral studies from McGill University. He has authored more than 15 publication in the area of Molecular Biology and Cancer research during his doctoral studies.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version