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Natural Extracts From Marine Environment : A Source Of Anticancerous Compounds | 9574
ISSN: 2155-9910
Journal of Marine Science: Research & Development
Open Access
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Due to the high side effect of synthetic product researchers studied extensively on the secondary metabolites from Marine
sources which can be utilized as potential drugs. Another reason for searching marine source is the biodiversity of a source
which is abundant. Researchers from FAU Harbour branch able to discover drugs from marine sources which are very effective
against deadly disease like Cancer, Alzheimer's disease, ocular diseases & other inflammation. Basically the secondary metabolites
produced by marine animals like sponge, coral, algae are very effective. Here we can take some example: Ziconotide from cone
snail used for treatment of pain ( USFDA approved-2004), Trabectedin ( European Union approved), spongouridine and
spongothymidine from a sponge (
Cryptotheca crypts
), were used for cancer treatment. Some other antitumor compound include:
Aplidine from tunicate (
Aplidium albicans
)
effective against renal & medullary thyroid carcinoma
& Neuro endocrine tumors,
Agelasphins from an Okinawan sponge, Bryostatin I from the
Bulgula neritina
, Discodermolide, from sponge
Discodermia
dissoluta
. Dolastatins from the Indian Ocean sea hare
Dolabela
having anti neoplastic activity
, halichondrin (
Halichondria okadai
constituent
)
has tumor inhibitory activity
. Spisulosine from
Spisula polynyma
has antiproliferative activity against cancer cell lines.
Squalamine from the dogfish shark, (
Squalus acanthias
)
has anti angiogenesis activity
. Ecteinascidin from tunicate (
Ecteinascidia
turbinata
) act against sarcomas. From a report of FDA Currently 2 anticancer drugs : Cytarabine & Eribulin approved by the FDA
are in phase III trial, 118 Marine natural products are in preclinical trial, 22 during clinical trial & 3 on the market.
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