alexa Pathogenesis Of Skin Injury Of Systemic Lupus Erythematosus (SLE)
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Epidemiology & Evolutionary Genetics
August 18-19, 2014 DoubleTree by Hilton Beijing, China

Guo-Min Deng
ScientificTracks Abstracts: Epidemiol
DOI: 10.4172/2161-1165.S1.006
Abstract
S ystemic lupus erythematosus (SLE) is an autoimmune disease characterized by high levels of autoantibody and multi-organ tissue damage. Skin injury is the second most common manifestation in patients with SLE, yet the etiology and pathogenesis of skin injury in SLE remains unclear. In this review, we discuss the role of lupus serum IgG in the mechanism of skin injury of SLE based on our recent findings. Compared to skin of healthy individuals, there is a large amount of IgG deposition in skin of patients with SLE. Serum from SLE patients and lupus-prone mice induces skin inflammation following intradermal injection into normal mice. Lupus serum depleted of IgG failed to cause skin inflammation. Monocytes, but not lymphocytes, were found to be crucial in the development of lupus serum-induced skin inflammation, and lupus serum IgG induced monocyte differentiation into dendritic cells (DCs). TNF- α and TNFR1, but not TNFR2, were required for the development of lupus serum-induced skin inflammation. TNFR1 inhibitor but not TNFR2 inhibitor suppressed skin injury in lupus -prone mice. Spleen tyrosine kinase (Syk) is involved in Fc γ R signaling transduction, inhibition of Syk in lupus-prone mice prevented the development of skin disease and significantly reduced established skin disease. These studies demonstrated that disruption of the TNFR1-mediated signaling pathway and blockade of DC generation and IgG- Fc γ R signaling transduction may prove to be of therapeutic value in patients with cutaneous lupus erythematosus.
Biography
Guo-Min Deng has graduated from Tongji Medical University and Peking Union Medical College with MD in 1988 and MS degree in1994. He obtained his PhD from Gothenburg University in Sweden in 2001. He completed his Postdoctoral training in National Institutes of Health in Maryland, USA during 2002-2006. He became as an instructor in Harvard Medical School in 2006 and became Assistant Professor in Harvard University in 2011 in Boston, USA. He accepted a position of distinguished Professor in Nanjing Medical University in 2012. His research field is "pathogenesis and therapy of autoimmune diseases".
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords