Phylogeography, Gene Exchange, And The Evolution Of Antibiotic Resistance In Mycoplasma Hyopneumoniae | 17912
Epidemiology: Open Access
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is a major pathogen living in swine respiratory tracts and causes porcine enzootic pneumonia,
a highly contagious and chronic disease. To explore the evolution of this pathogen, whole genomes of 117
strains collected from pigs in four different countries between 1969 and 2011 were sequenced. Initial analyses suggested that
the standard diagnostic techniques had confused
with the non-pathogenic
flocculare in some
cases, and also revealed evidence of gene exchange between the two species, but not with the related pathogen
Bayesian phylogeographic analysis carried out on our study suggested complete clustering of
source country, despite widespread gene exchange within, but not between countries. This is surprising given the widespread
transport of pigs between these countries, and the absence of known reservoirs for the pathogen. Finally, the evolution of
known antibiotic resistance genes was examined, and demonstrated repeated evolution of quinolone resistance in UK farms,
consistent with use of these antibiotics in pigs in the UK. Together the results showed the utility of whole-genome sequencing,
combined with evolutionary analyses, for understanding the epidemiology and emergence of infectious disease.
Fang Wang has completed her Master?s degree in Southeast University, China, 2012 at the age of 25 and is currently a second year PhD student in Welch
group, Department of Genetics, University of Cambridge, UK. Her research mainly involves on studying the pathogen genome evolution, with special focus on
Staphylococcus aureus and Mycoplasma hyopneumoniae.
She is interested in the genomic changes for bacteria transmission between different hosts and different
locations. She is also interested in understanding the genetic evolution of bacteria in antibiotic resistance.
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