alexa
Reach Us + 44-1753390542
Progression Of Primary Pneumonic Plague In A Mouse Model | 5399
ISSN: 2157-2526

Journal of Bioterrorism & Biodefense
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Progression of primary pneumonic plague in a mouse model

International Conference on Biothreats & Biodefense

Suppiah Paramalingam Sivalingam, Chern Chiang Siew, Grace C Chang, Boon-Huan Tan and Eric Peng Huat Yap

ScientificTracks Abstracts: J Bioterr Biodef

DOI: 10.4172/2157-2526.S1.002

Abstract
Yersinia pestis (YP) causes plague, and its potential for aerosol dissemination and rapid disease progression are of particular concern for defence against bioterrorism. The high morbidity and mortality rates associated with plague and the recent emergence of multidrug resistance makes YP a potential threat to humans. Growth of YP at temperatures of the flea vector (28? C) and of the mammalian host are known to induce different proteins, contributing to different virulence. Here, a study comparing the disease progression of YP in a primary pneumonic mouse plague model following pre-incubation at 28? C and at 37? C was conducted. Mice were exposed to two inhalational (intranasal and aerosol) routes of infection and the LD50, bacterial dissemination, cytokine/chemokine production, and tissue damage at different time points over the course of infection were determined. Pre-incubation of YP strain NCTC144 at 37? C increased tissue dissemination and disease progression between 48 and 72h compared to at 28? C. In both intranasal and aerosol model of infection there was an increase in the severity of tissue injury that correlated with increased cytokine/chemokine expression at 37? C. In the intranasal route, there was a distinct difference in infection pattern between the two temperatures, with virulence higher at 37? C. This distinction was absent in the aerosol model. The present study correlates well with earlier reports of YP disease pattern in mice. Our study further confirms that the virulence and pathogenesis of YP are dependant on incubation conditions and route of infection
Biography
Top