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infections during pregnancy can result in abortion or congenital defects. Prevalence and risk
factors of toxoplasmosis in women of child-bearing age in Ethiopia are unknown. The current study was conducted with the
objectives of estimating the seroprevalence and potential risk factors in acquiring
infection by women of child-bearing
age in Central Ethiopia.
A cross-sectional study was conducted from March 2011 to September 2011. Sera of 425 women were analyzed by
indirect enzyme linked immunosorbent assay (ELISA). A questionnaire survey was administered for all study participants to
gather information on risk factors.
The study revealed that anti-
IgG antibodies were detected in 81.4% of the samples of which78.4% were positive
for only IgG and 3.06% positive for both IgG and IgM antibodies. Seroprevalence of IgM antibodies to
CI: 2.14, 5.86) was suggestive of recent infections. Of the 213 pregnant women9 (4.2 %) were IgM reactive. Out of 17 potential
risk factors investigated, univariate logistic regression showed significant association of
infection with study area,
age, pregnancy status, raw vegetable consumption, source of water, presence of cats at home, contact with cats, HIV status and
precaution during cats? feces cleaning (P ≤ 0.05). The final logistic regression model revealed that: the probability of acquiring
infection by women of Debre-Zeit was 4.46 times (95% CI of adjusted odds ratio [aOR]: 1.67, 11.89; P =0.003)higher
compared to women of Ambo, pregnant women were twice (95% CI aOR: 1.13, 3.59; P = 0.018) more likely to be seropositive
than non-pregnant women and women who consume raw vegetable were at increased risk of infection (aOR = 2.21, 95% CI: 1.03,
4.78; P = 0.043) than women who didn?t consume.
The seroprevalence of
infection in women of child-bearing age in Central Ethiopia is high. Study area,
pregnancy and raw vegetable consumption are risk factors to acquire
infection. Educational program, antenatal
screening of pregnant women and further epidemiological studies to uncover the economic and health impact of toxoplasmosis
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