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he selective advantage of the ?S?is very controversial in many studies. The objective was to find the existence, to determine
the prevalence and the type of severe malaria in different forms of sickle cell anemia. This study is retrospective, descriptive
and transversal, for 6 years (2005-2011) in Bonzola Hospital (central DR Congo). The diagnosis of sickle cell anemia was done
after electrophoresis of hemoglobin and the diagnosis of severe malaria was done after a positive test and classified according
with WHO criteria. 338 children have found to have developed severe malaria during the period of our study, 20 of them
were found to have type S hemoglobin which accounts to 5.9% of the whole subjects chosen. 65% of subjects were between
4 and 9 years. The male sex was more predominant than female (sex ratio=1.5).The AA hemoglobin phenotype represent
94.8% of cases (368/388), RR=1.17. 3 forms of severe malaria was found in sickle cell children (AS or SS): anemia in 1.02%,
hypoglycemia in 1.55% (RR=1.55), hemoglobinuria in 2.57% (RR=4.5). The parasitemia rate is more important concerning AS
children (12/20) than SS children (8/20).
Our study showed that severe malaria can occur on sickle cell anemia subjects. Doing further analytical studies would help
investigate the biological implications of P. falciparum in sickle cell anemia.
Oscar Luboya Numbi is a pediatrician since more than 20 years, and a pioneer of public Health in DR Congo. Currently he held the position as the chief of Pediatric
Department at University of Lubumbashi. He is also the provincial president of the Congolese Society of Pediatric. He teaches in more than six universities and
have publish locally and internationally many papers.
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