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Dead end (dnd) is a vertebrate-specific component of germ plasm that is crucial for primordial germ cell migration and survival
in zebrafish. In this study, we identified a
) in turbot (
) and investigated its
expression pattern during embryogenesis and gonadal development. It showed that the predicted amino acid sequence of isolated
cDNA shared high identity to Dnd homologues and was classified to its teleost counterparts. RT-PCR and
transcripts could be detected in germ cells, including primordial germ cells (PGCs), adult male and
female germ cells. Furthermore, the female exhibited higher expression of
than male before sex maturation. This difference
reduced gradually due to the up-regulation of
in male gonad after the spermatogonia proliferated and meiosis proceeded.
The results not only suggest the conserved role of
in germ cell development in turbot, but also provide the initial evidence for
its possible involvement in sex differentiation and gametogenesis in teleosts.
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