alexa Sodium/potassium ATPase And Oxidative Damage: A New Paradigm For Development Of Anti-cancer Drugs?
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Epidemiology & Evolutionary Genetics
August 18-19, 2014 DoubleTree by Hilton Beijing, China

Chia-Chi Liu
ScientificTracks Abstracts: Epidemiol
DOI: 10.4172/2161-1165.S1.006
Abstract
T he Na + -K + pump is a membrane protein that catalyses bi-directional ATP dependent transport of sodium and serves a significant role in cell growth, differentiation and cell death. We have developed a protein-based therapeutic approach to target the pump in cancer cells centered on a novel molecular mechanism for regulation of the pump activity. The mammary tumor protein 8 (or ?Mat8?) is well recognized and overexpressed in cancers such as prostate, breast and pancreas. Mat8 is recognized for its close association with the Na + -K + pump and its ability to modulate the pump?s functional characteristics. We have demonstrated that glutathionylation, a specific oxidative modification of the β1 Na + -K + pump subunit is induced by oxidative stimuli and results in pump inhibition. Reversal of glutathionylation depends on the specific cysteine residues of Mat-8 proteins. We hypothesize that Mat8 proteins protect pump function against inhibition due to the high levels of oxidative stress that cancer cells typically encounter. Preliminary results indicate that overexpression of Mat8 in breast cancer cells protect against treatment-induced oxidative stress. A cysteine-mutated Mat8 ?loss-of-function? derivative (Cysless Mat8) can displace wild type within the membrane of Na + -K + pumps and abolish its role in reversing oxidative inhibition of the pump. Results also suggest that silencing wild type Mat8 protein with a loss-of-function derivative may greatly strengthen the efficacy of treatments that increase oxidative stress within tumors. This ongoing study endeavors to develop amalgamated novel treatments for cancer patients while alleviating side effects associated with traditional therapy and improve overall patient well-being.
Biography
Chia-Chi Liu is a Research Fellow at the University of Sydney. She completed her PhD in Chemistry and Bio-molecular Science from Macquarie University. Her core research focus is investigating the relationship between oxidative stress and the sodium pump function. Her research interests include the development of new diagnostic methods for oxidative damage of the pump; the discovery of new drugs for heart disease; and the design of novel therapeutic proteins for cancer treatment. Since 2009, she published more than 20 high impact factor publications with peer-reviewed journals and is the inventor for an innovative patent in diagnostic technology.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords