alexa Sodium/potassium ATPase And Oxidative Damage: A New Paradigm For Development Of Anti-cancer Drugs? | 17880
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

Annual meet on Epidemiology and Public Health

Yokohama, Japan
Share This Page
 

Sodium/potassium ATPase and oxidative damage: A new paradigm for development of anti-cancer drugs?

2nd International Conference on Epidemiology & Evolutionary Genetics

Chia-Chi Liu

ScientificTracks Abstracts: Epidemiol

DOI: 10.4172/2161-1165.S1.006

Abstract
T he Na + -K + pump is a membrane protein that catalyses bi-directional ATP dependent transport of sodium and serves a significant role in cell growth, differentiation and cell death. We have developed a protein-based therapeutic approach to target the pump in cancer cells centered on a novel molecular mechanism for regulation of the pump activity. The mammary tumor protein 8 (or ?Mat8?) is well recognized and overexpressed in cancers such as prostate, breast and pancreas. Mat8 is recognized for its close association with the Na + -K + pump and its ability to modulate the pump?s functional characteristics. We have demonstrated that glutathionylation, a specific oxidative modification of the β1 Na + -K + pump subunit is induced by oxidative stimuli and results in pump inhibition. Reversal of glutathionylation depends on the specific cysteine residues of Mat-8 proteins. We hypothesize that Mat8 proteins protect pump function against inhibition due to the high levels of oxidative stress that cancer cells typically encounter. Preliminary results indicate that overexpression of Mat8 in breast cancer cells protect against treatment-induced oxidative stress. A cysteine-mutated Mat8 ?loss-of-function? derivative (Cysless Mat8) can displace wild type within the membrane of Na + -K + pumps and abolish its role in reversing oxidative inhibition of the pump. Results also suggest that silencing wild type Mat8 protein with a loss-of-function derivative may greatly strengthen the efficacy of treatments that increase oxidative stress within tumors. This ongoing study endeavors to develop amalgamated novel treatments for cancer patients while alleviating side effects associated with traditional therapy and improve overall patient well-being.
Biography
Chia-Chi Liu is a Research Fellow at the University of Sydney. She completed her PhD in Chemistry and Bio-molecular Science from Macquarie University. Her core research focus is investigating the relationship between oxidative stress and the sodium pump function. Her research interests include the development of new diagnostic methods for oxidative damage of the pump; the discovery of new drugs for heart disease; and the design of novel therapeutic proteins for cancer treatment. Since 2009, she published more than 20 high impact factor publications with peer-reviewed journals and is the inventor for an innovative patent in diagnostic technology.
Top