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ea catechin epigallocatechin-3-gallate (EGCG) and other polyphenols, such as theaflavins (TFs), are increasingly proving
useful as chemopreventives in a number of human cancers. They can also affect normal cells. The polyphenols in tea are
known to have antioxidant properties that can quench free radical species, and pro-oxidant activities that appear to be responsible
for the induction of apoptosis in tumour cells. The bioavailability of these natural compounds is an important factor that
determines their efficacy. Nanoparticle (NP)-mediated delivery techniques of EGCG and TFs have been found to improve their
bioavailability to a level that could benefit their effectiveness as chemopreventives. The results of DNA damage measurements
by the Comet assay revealed opposite trends in bulk and NP forms of TFs, as well as EGCG. Both the compounds in the bulk
form produced statistically significant concentration-dependent reductions in DNA damage in oxaliplatin- or satraplatin treated
lymphocytes. In contrast, when used in the NP form both TFs and EGCG, although initially causing a reduction, produced a
concentration-dependent statistically significant increase in DNA damage in the lymphocytes. These observations support the
notion that TFs and EGCG act as both antioxidants and pro-oxidants, depending on the form in which they are administered
under the conditions of investigation.
Diana Anderson currently holds the Established Chair of the Division of Biomedical Sciences at the University of Bradford, UK. She obtained her first
degree in the University of Wales and second degree in the Faculty of Medicine, University of Manchester. After tutoring at the University of Sydney,
Australia, she became a research worker in the Department of Cancer Studies at the University of Leeds and at the Paterson Laboratories, Christie
Hospital, Manchester. She has organized both national and international meetings and was/is a member of various national (e.g. MRC Advisory
Board, Veterinary Products Committee) and of international committees, including the European Union Scientific Committee for Animal Nutrition
(SCAN). She recently won a prize as an Enterprise Fellow. She has hosted and participated in 56 meetings for WHO/IPCS. She is a consultant for
many international organizations, such as the WHO, NATO, TWAS, UNIDO and the OECD.
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