Time To Move Forward: Looking At Microbes By The View Of Single Cell Technologies | 9498
Journal of Marine Science: Research & Development
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It is well known that cultivation techniques do not recover the vast majority of uncultured microbes in nature. To circumvent
these limitations, past and current efforts based on metagenomics have significantly and unquestionably broadened our
knowledge in microbial ecology. However, despite improvement of assembly, metagenomics largely fails to recover discrete
genomes from uncultured microorganisms. Recently, single cell genomics has emerged as a new and powerful strategy in microbial
ecology, opening thus new avenues to disentangle the genomic information of most uncultured microbial groups. Outstanding
publications on marine environments have for instance identified major polysaccharide bacterial degraders in planktonic systems.
In addition, the in situ interaction of major protist and prokaryote groups has also partly elucidated. Another powerful example is
the discovery of chemolithoautotrophic pathways in uncultured Proteobacteria in the vast unknown mesopelagic environments.
These together with other studies are only the tip of the iceberg and we will see a boom of single cell genomics in the coming years.
Sitting down writing here the last sentences, I am thinking about what ́s next within this ?
??: maybe single virus
genomics might help us to decipher the genomic diversity of major environmental or pathogenic viruses? Or might be single cell
transcriptomics?... Whatever it comes from looking at individual microorganisms without missing the whole picture of microbial
communities view (i.e. -omics technologies) and linking that with comprehensive experiments in the lab, I will embrace it.
Manuel Mart?nez-Garc?a was graduated with full marks and honors in Biology from the University of Alicante (Spain) and received his PhD in Molecular
Microbial Ecology in 2005. He conducted three short postdoctoral European stays in reputed research centres such as the Max Planck Institute for
Marine Microbiology (Germany). During 2009-2011, he developed cutting-edge techniques on Single Cell Genomics combined with Metagenomics
to study the metabolic capabilities of uncultured microbes at the Bigelow Laboratory for Ocean Sciences (Maine, USA). He has published several
papers in high-impact journals based on single cell technologies. Currently, he is back to Spain as assistant professor in Microbiology and is serving
as an editorial board member of the Oceanography-Open Access Journal.
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