What Role Does The Environment Play In Longevity- Epigenetic Approach | 12895
Epidemiology: Open Access
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
ging is a risk for numerous chronic diseases such as cardiovascular disease and type 2 diabetes mellitus,
affecting the quality of life and lifespan. Epigenetics (acquired or heritable changes in gene function or
phenotypes without changes in DNA sequence), has emerged as an important factor in gene expression and
disease risk. We focused on epigenetic modifications involving cytosine methylation, which have been shown
to be associated with cancer risk and autoimmune disorders such as Lupus. Methylation levels at specific sites
appear to change with aging mostly through hypermethylation and we have been the first to show the magnitude,
bi-directionality and the genomic context of over million C-G island methylation sites in a rodent model of aging.
This has led us to hypothesize that
the pattern of methylation acquired with aging may be a central mechanism
predisposing the elderly to many age-related diseases and affecting healthy lifespan.
We utilized our Longevity
cohort, which assembled a cohort of centenarians (frequency of 1 in 5,000 in the population) and their offspring,
and studied their phenotype and genotype (candidate genes, GWAS and EWAS approaches). Our preliminary data
shows a dramatic difference between patterns of methylation in centenarians compared with younger subjects. We
have used a state of the art technology to achieve significant information on the changes in methylation with aging
and also assess the inherited patterns between centenarians and their offspring. Our analysis led to explore the
association with age-related diseases, and open the horizons for more specific and functional studies, as previously
exemplified by GWAS studies
Gill Atzmon is our eminent Editor- in- chief for Hereditary Genetics: Current Research, OMICS Publishing Group. He is the Associate
Professor in the Department of Medicine, Assistant professor in the Department of Genetics, Faculty Senate representative, Director of
the Genetic Core for LonGenety, Institute for Aging Research and the DRTC and also Director of Einstein SAR Research Program in the
Albert Einstein College Of Medicine, New York, USA. From 2005- 2009 he was the Director of the Quantitative PCR Core, Institute for
Aging Research and the DRTC, AECOM, NY. From 2005-2006 Instructor, 2004-05 Research Associate in the Department of Medicine
and was the Fellow in Human Genetics from 2001-04.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals