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Dr. Porjesz is a leading research expert in alcoholism, neurophysiology and genetics. Her research over the past 40 years has transformed the way researchers and professionals understand the relationships between genetics and alcohol, and the underlying factors that predispose a person to alcohol use disorders (AUDs).Early in her career, Dr. Porjesz discovered subtle deficits in the brain function of alcoholics. Her initial fascination with alcoholism was sparked by her observations that some alcoholics would repeatedly relapse despite their best intentions to remain abstinent. She published several seminal scientific studies detailing various aspects of brain dysfunction in abstinent alcoholics, and noted that many who had stopped drinking continued to experience sensory and cognitive deficits. While some of these deficits improved with abstinence from alcohol, others did not, even after ten years of abstinence. One such deficit that did not improve with long-term abstinence was the lower than normal amplitude of the P3 or P300 brain wave, a large signal indexing the brain’s ability to selectively respond to significant stimuli.
alcoholism, neurophysiology and genetics
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