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One of the most important goals in drug abuse research is to identify effective targets and strategies for preventing drug use, addiction and associated side effects. Our laboratory has a long standing interest in analysis of signal transduction pathways that underlie these behavioral and neurochemical responses to psychostimulants, cocaine and amphetamines and synthetic cannabinoids in male and female animals. The immense abuse potential of psychostimulants leading to behavioral sensitization, alterations in sleep, anxiety and aggressive behaviors and neurotoxic effects leading to permanent changes in striatal, cortical and hippocampal neurochemistry and function produce motor learning, cognitive and memory deficits and may predispose these individuals to neurological disorders such as Parkinson's disease. We use our expertise in molecular and behavioral techniques in vivo and in vitro to study the interactions between dopamine and glutamate receptors and their signaling pathways in drug addiction and neuronal degeneration.Drugs of Abuse, gene expression, neurochemistry and neuropharmacology, CNS degenerative diseases.
Research Article: J Addict Res Ther 2015, 6:236
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