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Dr. Kurosu has a long-term interest in development of new antibacterial agents targeting novel or unexploited drug targets. In order to develop novel antibacterial molecules, he develops concise syntheses of relatively complex molecules, and designs chiral molecules and generates small optimized libraries. He also develops convenient assays against target enzymes of interest. These efforts have resulted in the discovery of several new drug leads effective against MDR-Gram-positive pathogens including MDR-M. tuberculosis. Over the last 10 years, he has studied electron transport system, menaquinone biosynthesis, unexploited peptidoglycan biosynthesis, and bacterial kinases.
Synthesis and Biological Evaluation of Biologically Active Natural Products, Rational drug design, bioorganic chemistry, Development of Enzymatic Assays of Small Molecules, and New Chemical Tools.
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