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Nonclassical molecules (MHC class IB) exhibit limited polymorphism and expression than MHC Ia. It may be recognised by specific subsets of T-cell receptors or by innate immune receptors. Owing to their recognition by a more restricted set of receptors, MHC‐Ib are able to elicit a rapid response from immune cells and are, therefore, regarded as part of the innate immune system. Some MHC‐Ib act as antigen presenting structures, whereas others are recognised as direct ligands for immune receptors.
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