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Dr. Jean is presently the Chief of the Molecular Neuropsychiatry Research Branch and Associate Director for Diversity and Outreach at the Intramural Research Program (IRP) of NIDA. He received my MD degree from Columbia University College of Physicians and Surgeons in 1979. After a Psychiatry residency at Columbia University and a Neurology Residency at Mount Sinai Medical Center in New York City, he joined the NIMH-IRP as a Neuropsychiatry Fellow from 1984-1987. He was an Assistant Professor of Neurology and Psychiatry at Columbia University in NYC before joining the NIDA-IRP in 1992. He have published extensively on the cellular and molecular mechanisms of METH-induced neurodegeneration and on the cognitive effects of marijuana and cocaine.
Research in our section focuses on studies the molecular and cellular mechanisms of stimulant-induced toxicity. Dr. Cadet’s group has provided evidence that methamphetamine (METH) can cause widespread cell death in the rodent brain. These results have stimulated a whole new view of looking at METH-induced neurodegeneration.
We are presently investigating the possibility that these alterations might be related to drug-induced epigenetic changes in the ventral and dorsal striatum
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