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I have a broad background in gastrointestinal epithelial biology, tumor biology, and molecular and cellular biology with specific training and expertise in key research areas. As a postdoctoral fellow at the Massachusetts General Hospital (1993-1996), I investigated cell-cycle regulation via cyclin D1 and the transcriptional regulation of genes in the esophageal squamous epithelium; and developed the first transgenic mouse model of esophageal squamous cell carcinoma (ESCC). At Penn GI Division (1998-2019), I expanded my research to study EGFR, Notch and other molecules essential in ESCC intra-tumoral cancer cell heterogeneity (e.g. CD44) and environmental risk factors (e.g. alcohol) for esophageal carcinogenesis.
Perinatal 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) exposure affects various motivated behaviors controlled by limbic system of the brain in offspring. In this study, effects of perinatal TCDD exposure on taste preference were investigated in the rat offspring whose dams were orally exposed to TCDD on the 15 gestational days. After weaning, offspr... Read More»
Research Article: J Addict Res Ther 2014, 5: 173
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