Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Biological Targets For Medication Development In Stimulant Addiction: Focus On Animal Models Of Addictive-like Behavior | 8728
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 4859

Journal of Addiction Research & Therapy received 4859 citations as per Google Scholar report

Journal of Addiction Research & Therapy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • SafetyLit
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Biological targets for medication development in stimulant addiction: Focus on animal models of addictive-like behavior

2nd International Conference and Exhibition on Addiction Research & Therapy

Juan J. Canales

ScientificTracks Abstracts: J Addict Res Ther

DOI: 10.4172/2155-6105.S1.011

There continues to be an enormous unmet need for prevention, treatment, care and support for those who suffer from stimulant addiction. Research into treatment for problematic stimulant abuse has yet to find a suitable pharmacotherapeutic agent to assist with detoxification, withdrawal, and relapse prevention. The dopamine transporter (DAT) still constitutes a major target for the development of more effective pharmacotherapies for stimulant addiction. The rationale for targeting the DAT in stimulant abuse is fuelled by the existence of slow-onset, long-acting DAT inhibitors with weak stimulant and reinforcing effects, which can be used as a substitute. The recently designed generation of benztropine (BZT) derivatives includes compounds with high affinity for the DAT and markedly low abuse liability. I will present evidence that we and others have accumulated in recent years demonstrating that BZT derivatives show psychopharmacological features consistent with those of an ideal replacement or substitute treatment. BZT analogues, such as AHN-1055 and JHW 007, block cocaine-induced stimulant-induced locomotor stimulation, sensitization, reward and reinforcement, and can mitigate relapse to drug seeking behavior. I will also discuss the potential role of the newly discovered trace amine associated receptor 1 (TAAR1) as a receptor target for medication development in stimulant abuse. There is evidence of functional regulation of DAT activity by TAAR1, which is activated directly by amphetamine, methamphetamine, and MDMA. Recent preclinical data suggests that compounds with activity at TAAR1 may be promising pharmacotherapies in stimulant addiction

Juan J. Canales is an Associate Professor in Behavioral Neuroscience at the University of Canterbury, New Zealand. He completed his Ph.D. at the University of Oxford, UK, in 1997 and has conducted research at the Massachusetts Institute of Technology, USA, and the University of Valencia, Spain. His research focuses in the neurobiology and neuropharmacology of addiction and addiction-related disorders, and the impact of drugs on cognitive function. He is the Editor-in-Chief of the Journal of Behavioral and Brain Science and serves in the editorial board of several other scientific journals

Relevant Topics