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Charnoly Body As A Novel Biomarker In Drug Addiction | 30472
ISSN: 2155-6105
Journal of Addiction Research & Therapy
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Charnoly body (CB) is a pre-apoptotic biomarker of compromised mitochondrial bioenergetics, which is formed in the most
vulnerable cell in response to nutritional stress, environmental toxins, or drug of abuse due to free radical overproduction
and mitochondrial genome down-regulation. It is detected as a pleomorphic multi-lamellar, electron-dense, membrane stack of
degenerated mitochondrial membranes in the hippocampal CA-3 and dentate gyrus neurons, hypothalamic neurons, and cerebellar
Purkinje neurons in animal models of fetal alcohol syndrome, Parkinson?s disease, Alzheimer?s disease, vascular dementia, and
chronic drug addiction. Accumulation of CB at the junction of axon hillock impairs axoplasmic flow in the synaptic terminals
to cause cognitive impairments, early morbidity, and mortality in chronic drug addiction. Initially ?? collapse, down-regulation
of mitochondrial -NADH-oxidoreductase, and 8-OH-2dG can be detected as CB rudiments to evaluate early symptoms of acute
drug addiction as epigenetic modulators of DNA methylation and histone acetylation. During chronic phase, CB formation can
be detected at the ultrastructure level. Antioxidants such as Metallothioneins, inhibit CB formation as free radical scavengers by
regulating zinc-mediated transcriptional activation of genes involved in growth, proliferation, and differentiation as established in
gene-manipulated human dopaminergic (SK-N-SH and SHY5Y) cells and in mouse models of multiple drug abuse. Hence novel
drugs may be developed to prevent CB formation or induce charnolophagy as an efficient molecular mechanism of intracellular
detoxification during acute phaseand novel CB antagonists to avert chronic drug addiction by employing CB as an early, sensitive
and specific biomarker to detect, prevent and effectively treat drug addiction.
Biography
Sushil Sharma is a Professor of Pharmacology & Course Director at Saint James School of Medicine, Kralendijk, Bonaire, Dutch Caribbean.
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