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Differences In The Activity Of The HPA-Axis In Non-alcoholic Females As A Function Of Family History Of Alcoholism | 4213
ISSN: 2155-6105
Journal of Addiction Research & Therapy
Open Access
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ulnerability to alcoholism is determined by the interplay of genetic and environmental factors such as stress. A number
of studies have demonstrated differences in the activity of the HPA-axis under basal conditions and in response to alcohol
and stress as a function of family history of alcoholism. Most of the studies have been performed using male participants.
Though males present a higher incidence of alcoholism than females, alcoholism is observed in females, while there is evidence
for a higher incidence of alcoholism in the daughters of alcoholic parents. The present studies test the hypothesis that there are
differences in the activity of the HPA-axis under basal conditions and in response to stress and alcohol between non-alcoholic
females with and without a family history of alcoholism. Participants were between 18-30 years old. The response of the HPA-
axis to placebo or alcohol containing drinks and to a stress task was determined by measuring plasma ACTH and cortisol
concentrations prior to and at specific time points following the drink and performance of the stress task. Results demonstrated
higher basal levels of ACTH and cortisol as well as a higher response to alcohol and stress in females with a family history of
alcoholism. Consumption of an alcohol drink attenuated or prevented the stress induced increase of both ACTH and cortisol
regardless of the family history. Thus, non-alcoholic females present differences in the activity of the HPA-axis as a function of
family history of alcoholism which may be important in determining vulnerability for alcohol abuse
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