Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Dopamine D1 And D2 Receptor Subtypes Functional Regulation In Unilateral Rotenone Lesioned Parkinson’s Rat Model: Effect Of Serotonin, Dopamine And Norepinephrine | 62163
Journal of Addiction Research & Therapy
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Parkinson’s disease (PD) is due to widespread degeneration in the central and peripheral nervous systems. The hallmark
pathology remains in the dopaminergic striatal insufficiency and degeneration of dopaminergic neurons in the substantia
Objectives: - The present study analysed the effect of serotonin (5-HT), dopamine and norepinephrine (NE) as treatment on
rotenone induced hemi-Parkinson’s disease in rats and its role in the regulation of Dopamine receptor subtypes in the Corpus
Straiatum (CS) of the experimental rats.
Methods: - Unilateral stereotaxic single dose infusions of rotenone were administered to the substantia nigra of adult male
Wistar rats. Neurotransmitters –serotonin (5-HT), dopamine and norepinephrine (NE) treatments were given to rotenone
induced hemi-Parkinson’s rats. Dopamine receptor and its subtypes (D1 and D2) binding assay were done. Gene expression
studies of Dopamine D1 and D2 were done using real-time PCR.
Results: - Scatchard analysis of Dopamine and Dopamine D2 receptor showed a significant increase (p<0.001) and Dopamine
D1 receptor showed a significant decrease (p<0.001) in the Bmax in Corpus Striatum of the PD rats compared to control. These
altered parameters were reversed to near control in the serotonin and norepinephrine treated Parkinson’s disease rats and no
change was observed in Dopamine treated Parkinson’s disease rats. Real-time PCR results confirmed the receptor data.
Conclusion: - Our results showed serotonin and norepinephrine functionally reversed in Dopamine receptors in rotenone
induced hemi-Parkinson’s rat. This has clinical significance in the therapeutic management of Parkinson’s disease.
Key words: Corpus Striatum; Dopamine D1 and D2 receptor subtypes; Parkinson’s disease; Rotenone; Substantia nigra pars
Jes Paul is doing research on Stem Cell, Genetics, Medical Biochemistry, pathophysiology, Molecular and Cellular neurobiology. He worked as an Associate Research Scientist Texas Tech University Health Sciences Center. He did Post-doctoral researcher from Ohio State University Medical Center.