Mechanisms of pain and opioid pharmacology

Thersilla Oberbarnscheidt; Norman S Miller

doi:10.4172/2155-6105.C1.027

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5^th International Conference and Exhibition on Addiction Research & Therapy
October 03-05, 2016 Atlanta, USA

Thersilla Oberbarnscheidt and Norman S. Miller

Michigan University, USA
University of Florida, USA

ScientificTracks Abstracts: J Addict Res Ther

DOI: 10.4172/2155-6105.C1.027

Abstract

Opioid-induced hyperalgesia (OIH) is a very common consequence of pain management with opioids. Characteristics of OIH are worsening pain over time despite an increased dose of the opioid. It is often recognized neither by the physician nor the patient, and it results in increasing doses of opioid medications and continued unsatisfying pain levels experienced by the patient. The increased use of narcotics has a negative impact on patient outcome, as patients suffer from increased pain levels and often develop depression. Patients with OIH require frequent assessment for aberrant behaviors as an indicator of addictive use. Opioid-seeking behavior may complicate the clinical picture of failed opioid therapy. The treatment of OIH is to discontinue the opioid medication and to treat the patient’s withdrawal symptoms, if necessary, in an inpatient setting with medical monitoring.

Biography

Thersilla Oberbarnscheidt is a resident psychiatrist at Central Michigan University, Department of Psychiatry, College of Medicine, MI, USA. Thersilla got her medical degree from the Christian-Albrechts-University in Kiel, Germany and did her 4th Year medical training at Yale University, School of Medicine in New Haven, CT, USA. She received her PhD in Neuroscience from the Christian Albrechts- University in Kiel, Germany. Her thesis was on Phenazone in the treatment of the acute migraine attack. Cephalalgia. Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study.

Email: [email protected]

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Journal of Addiction Research & Therapy
Open Access