Peripheral And Central Mechanisms Of Methamphetamine: Connecting The Dots | 18018
Journal of Addiction Research & Therapy
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ethamphetamine is a drug that is abused worldwide. Emerging clinical studies are supportive of previous preclinical
findings from animals that illustrate methamphetamine injures dopamine and serotonin neurotransmitter systems.
Results will be presented from animal model studies that demonstrate oxidative and excitotoxic mechanisms are involved
which converge to mediate the toxic effects of methamphetamine on dopamine and serotonin neurons. Although these
neurochemical findings have traditionally been attributed to the direct action of methamphetamine on the brain, new
evidence will be presented indicating that the causes of the neurotoxicity are also initiated by the effects of the drug on systemic
organs and circulating small molecules. Moreover, additional studies will be described that demonstrate the toxic effects of
methamphetamine are not limited to neurotransmitter systems but also include protracted damage to brain endothelium that
comprises the blood-brain barrier. Overall, these recent studies broaden the scope of the causes and consequences associated
with the injurious effects of methamphetamine on the brain.
Bryan K Yamamoto received his PhD from Syracuse University in Neurobiology after which, he completed a postdoctoral fellowship in clinical pharmacology at
the University of Colorado Medical School. He is Professor and Chair of the Department of Neurosciences at the University of Toledo College of Medicine and Life
Sciences. He has been a member of NIH Study Sections since 1987 and a member of several advisory boards of NIH sponsored research centers and programs.
His research has focused on how drugs of abuse affect the neurochemistry of brain and has been funded continuously over the last 27 years by the NIH.
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