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Proteomic Alterations Of The Nucleus Accumbens Of Opioid Addiction And Withdrawal Intervention In Primate Models | 4221
ISSN: 2155-6105
Journal of Addiction Research & Therapy
Open Access
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I
t has been known that the reinforcing effects and long-term consequences of opioid are closely associated with nucleus
accumbens (NAc) in the brain, a key region of the mesolimbic dopamine pathway. However, the proteins involved in
neuroadaptive processes and withdrawal symptom in primates of opioid addiction have not been well explored. In the present
study, we performed proteomes in the NAc of rhesus monkeys of opioid addiction and withdrawal intervention with clonidine or
methadone. Two-dimensional electrophoresis was used to compare changes in cytosolic protein abundance in the NAc. We found
a total of 46 proteins differentially expressed, which were further identified by mass spectrometry analysis. The identified proteins
can be classified into 6 classes: metabolism and mitochondrial function, synaptic transmission, cytoskeletal proteins, oxidative
stress, signal transduction and protein synthesis and degradation. Importantly, we discovered 14 proteins were significantly
but similarly altered after withdrawal therapy with clonidine or methadone, revealing potential pharmacological strategies or
targets for the treatment of opioid addiction. Our study provides a comprehensive understanding of the neuropathophysiology
associated with opioid addiction and withdrawal therapy in primate models, which is helpful for the development of opiate
withdrawal pharmacotherapies
Biography
Qian Bu is studying his Ph.D from Sichuan University. He has published more than 6 papers in reputed journals including J Proteomics,
Neurotoxicology, Nanotechnology and so on
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