Journal of Addiction Research & Therapy
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The abuse of amphetamine-type-stimulants (ATS) represented by methamphetamine(MA)is becoming increasingly
popular year by year.Compared with some traditional drugs, MA has a characteristic of strong psychological dependence and
obvious neurotoxicity. Depression is the most common co-morbidity axis I disorder for individuals with MA abusers. The present
study aims to compare the structure changes of limbic system and other relative brain regions of young adult MA users with
control group and the relationship between structure changes with depression symptoms.
29 MA users aged between 18-25 years who met the criteria of Diagnostic and Statistical Manual of Mental Disorder
(DSM-IV) and 21 matched healthy control subjects participated in the study. We collected the clinical data, including generalized
information questionnaire, the information of drug use, questionnaires as HAMD-24,HAMA, PANSS in order to understand
their psychiatric syndromes and mood symptoms. Then, we performed 3T magnetic resonance imaging (MRI)scans of the brains
of the experimental group and the control group to find the structure impairment in some certain brain regions.
MA group have obvious mood disorder，such as depression and anxiety which is significantly different from the healthy
group(P<0.05). MA group have larger left amygdala volume, Right-Caudate volume, left-caudate volume, and gray matter total
volume with comparing to control group(P<0.05).
There are structural abnormality in some relative brain regions of MA users. In the future study, fMRI should be
performed to explore the functional changes of the brain regions that have structural abnormality, so that we could provide more
evidence for better clinical treatment plan
Jing Li is a Professor of the department of Psychiatry, Mental Health Centre of West China Hospital at Sichuan University, China. She is research
director of the Division of Substance Abuse at West China Hospital, the assistant editor of Addiction, the deputy secretary of Chinese Association
of Drug Abuse Privation and Treatment, and the director of national clinic trail centre of narcotic control medicine of West China Hospital. She has
been supported by a series Research Scientist Award from the Ministry of Science and Technology, the Ministry of Health of China since 2000. Her
current researches mainly focuses on substance dependence and psychopharmacology, including evidence-based treatment on alcohol, ATS and
heroin dependence, effect of traditional Chinese medicine, clinical trial of narcotic control medicine, and neuroimaging studies. She has published
over 100 papers, books and reviews
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