Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Unraveling The Role Of The Cerebellum In Drug Addiction: Old And Recent Ideas With A New Support | 4230
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 4859

Journal of Addiction Research & Therapy received 4859 citations as per Google Scholar report

Journal of Addiction Research & Therapy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • SafetyLit
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Unraveling the role of the cerebellum in drug addiction: Old and recent ideas with a new support

International Conference and Exhibition on Addiction Research & Therapy

Marta Miquel, Carla Sanchis-Segura, Dolores Vazquez-Sanromn and Mara Carb

Accepted Abstracts: J Addict Res Ther

DOI: 10.4172/2155-6105.S1.009

Addictive drugs compete with natural reinforces for neural plasticity mechanisms, reducing progressively the ability of those to maintain adapted behavior. Drug-induced neural plasticity mechanisms in prefronto-limbic-striatal circuitry have been proposed as responsible for the instauration and maintenance of addictive behavior. We propose that drug-induced plasticity in prefronto- cerebellar circuitry will be a central stage of behavioral modifications leading to addictive behavior. The reasoning that supports the current proposal is based on the follow premises and results: 1) the cerebellum is crucial for consolidation and long-term storage of pavlovian and instrumental memory; 2) the cerebellum connects with fronto-limbic-striatal circuitry; 3) addictive drugs alter cerebellar plasticity mechanisms; 4) we observed that a short experience with cocaine produced a robust c-Fos expression in the mouse medial prefrontal cortex. However, after prolonging cocaine experience, the cerebellum showed higher c-Fos expression than the prefrontal cortex. It is also important to study how environmental factors can protect the brain against drug effects. Recently, we focus on the possibility of extending cerebellar proliferative activity beyond the postnatal period by exposing mice to environmental enrichment. Our findings showed that an enriched environment increases the presence of newly generated neurons at the granular layer of the cerebellar cortex. Moreover, environmental enrichment maintained neurogenic activity in the cerebellum of those animals chronically treated with alcohol and cocaine. These results supports ways in which the cerebellum may be challenged and stimulated, making it possible to develop environmental therapeutic strategies to ameliorate the consequences of drug abuse.

Marta Miquel has completed her Ph.D at the age of 29 years from University of Valencia and postdoctoral studies from the Department of Pharmacology, University of Toronto and C.I.F.A (Faculty of Medicine), University of Navarra. Spain. Currently, she is tenure awarded professor in Psychobiology in the Faculty of Health Sciences. Jaume I University, (Spain) and invited research professor in the Brain Research Center, University of Veracruz (Mexico). She is the head of the research team Addiction and Neuroplasticity and has been the Ph.D advisor in 5 doctoral theses. She has published 40 papers in peer-reviewed international journals, and 7 books and chapters

Relevant Topics